HitPredict

Interactor 1: KHDR1 (Q07666)
KH domain-containing, RNA-binding, signal transduction-associated protein 1 (GAP-associated tyrosine phosphoprotein p62) (Src-associated in mitosis 68 kDa protein) (Sam68) (p21 Ras GTPase-activating protein-associated p62) (p68)
Gene: KHDRBS1

Interactor 2: SH3K1 (Q96B97)
SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1)
Gene: SH3KBP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.623

Property	Details
Experiments	22745667, 19531213, unassigned1973
Identification Methods	unspecified method, affinity chromatography technology, two hybrid fragment pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0017124 - SH3 domain binding
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 443 Hs			1 665
+	Hs
		1060010 KHDR1_HUMAN (1-443): 3.72e-177: 504: 100.00		CD2AP_HUMAN (1-664): 1.84e-95: 309: 32.36
+	Hs
		1059863 KHDR1_HUMAN (1-443): 3.72e-177: 504: 100.00		SPD2A_HUMAN (3-650): 8.88e-37: 150: 16.74
+	Mm
		1221217 KHDR1_MOUSE (1-443): 0: 514: 94.36		GRB2_MOUSE (2-158): 8.55e-35: 133: 20.37
+	Hs
		987575 KHDR1_HUMAN (1-443): 3.72e-177: 504: 100.00		GRB2_HUMAN (2-158): 8.55e-35: 133: 20.37
+	Mm
		1221433 KHDR1_MOUSE (1-443): 0: 514: 94.36		NCK1_MOUSE (104-413): 1.87e-26: 113: 16.92
+	Hs
		593973 KHDR1_HUMAN (1-443): 3.72e-177: 504: 100.00		NCK1_HUMAN (104-413): 3.74e-26: 112: 16.62
+	Hs
		1059878 KHDR1_HUMAN (1-443): 3.72e-177: 504: 100.00		DNMBP_HUMAN (4-581): 5.37e-24: 110: 12.50
+	Hs
		222063 KHDR1_HUMAN (1-443): 3.72e-177: 504: 100.00		NCK2_HUMAN (244-432): 3.03e-17: 86.2: 21.24
+	Hs
		292825 KHDR1_HUMAN (1-443): 3.72e-177: 504: 100.00		GRAP2_HUMAN (1-58): 2.52e-17: 85.5: 31.03
+	Hs
		1059850 KHDR1_HUMAN (1-443): 3.72e-177: 504: 100.00		ITSN1_HUMAN (77-423): 3.02e-14: 78.9: 14.56
+	Hs
		1059983 KHDR1_HUMAN (1-443): 3.72e-177: 504: 100.00		ITSN2_HUMAN (214-418): 8.13e-14: 77.4: 15.61
+	Hs
		584525 KHDR1_HUMAN (1-443): 3.72e-177: 504: 100.00		VAV_HUMAN (84-158): 6.3e-13: 74.3: 28.95
+	Mm
		1221265 KHDR2_MOUSE (100-443): 8.39e-126: 370: 61.65		GRB2_MOUSE (2-158): 8.55e-35: 133: 20.37
+	Dm
		1467319 Q9W255_DROME (59-398): 6.07e-96: 295: 32.35		Q9VA36_DROME (2-580): 3.86e-46: 177: 22.38
+	Hs
		292840 KHDR2_HUMAN (99-443): 5.2e-130: 381: 60.62		GRAP2_HUMAN (1-58): 2.52e-17: 85.5: 31.03
+	Hs
		222089 SF01_HUMAN (82-301): 6.66e-54: 192: 21.33		NCK2_HUMAN (244-432): 3.03e-17: 86.2: 21.24