HitPredict

Interactor 1: ACK1 (Q07912)
Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Tyrosine kinase non-receptor protein 2)
Gene: TNK2

Interactor 2: HSH2D (Q96JZ2)
Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X)
Gene: HSH2D

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	25814554, 11700021, unassigned1126
Identification Methods	two hybrid, affinity chromatography technology, enzymatic study, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1038 Hs			1 352
+	Hs
		440513 ACK1_HUMAN (1-1038): 0: 799: 100.00		FYN_HUMAN (4-211): 2.37e-61: 207: 19.40
+	Hs
		463070 ACK1_HUMAN (1-1038): 0: 799: 100.00		YES_HUMAN (4-211): 8.21e-58: 197: 19.40
+	Hs
		557254 ACK1_HUMAN (1-1038): 0: 799: 100.00		SRC_HUMAN (4-211): 1.74e-53: 186: 20.69
+	Hs
		463478 ACK1_HUMAN (1-1038): 0: 799: 100.00		LYN_HUMAN (16-211): 7.64e-52: 181: 17.73
+	Hs
		473406 ACK1_HUMAN (1-1038): 0: 799: 100.00		HCK_HUMAN (16-211): 1.1e-50: 178: 20.91
+	Mm
		236920 ACK1_MOUSE (1-1038): 0: 787: 92.70		SH2D7_MOUSE (4-303): 7.38e-55: 188: 20.51
+	Hs
		987579 ACK1_HUMAN (1-1038): 0: 799: 100.00		GRB2_HUMAN (16-188): 4.66e-43: 150: 20.11
+	Hs
		593976 ACK1_HUMAN (1-1038): 0: 799: 100.00		NCK1_HUMAN (10-121): 2.45e-16: 81: 30.17
+	Mm
		236934 ACK1_MOUSE (1-1038): 0: 787: 92.70		NCK1_MOUSE (10-121): 1.95e-16: 81.4: 30.17
+	Dm
		1061476 ACK_DROME (4-1030): 1.21e-170: 530: 29.96		GRAP_DROME (16-153): 5.3e-43: 149: 23.29
+	Hs
		362121 ABL1_HUMAN (1-975): 2.91e-146: 467: 19.01		FYN_HUMAN (4-211): 2.37e-61: 207: 19.40
+	Hs
		362143 ABL1_HUMAN (1-975): 2.91e-146: 467: 19.01		SRC_HUMAN (4-211): 1.74e-53: 186: 20.69
+	Hs
		362129 ABL1_HUMAN (1-975): 2.91e-146: 467: 19.01		HCK_HUMAN (16-211): 1.1e-50: 178: 20.91
+	Hs
		292795 ABL1_HUMAN (1-975): 2.91e-146: 467: 19.01		GRAP2_HUMAN (14-130): 8.17e-44: 155: 27.20
+	Hs
		362234 ABL1_HUMAN (1-975): 2.91e-146: 467: 19.01		GRB2_HUMAN (16-188): 4.66e-43: 150: 20.11
+	Mm
		97774 ABL1_MOUSE (1-975): 1.52e-152: 484: 20.02		E9PYG6_MOUSE (20-131): 3.89e-21: 96.8: 25.64
+	Mm
		362454 ABL1_MOUSE (1-975): 1.52e-152: 484: 20.02		NCK1_MOUSE (10-121): 1.95e-16: 81.4: 30.17
+	Hs
		362158 ABL1_HUMAN (1-975): 2.91e-146: 467: 19.01		RASA1_HUMAN (20-131): 1.7e-20: 94.9: 25.64
+	Hs
		362151 ABL1_HUMAN (1-975): 2.91e-146: 467: 19.01		NCK1_HUMAN (10-121): 2.45e-16: 81: 30.17
+	Hs
		362200 ABL1_HUMAN (1-975): 2.91e-146: 467: 19.01		ZAP70_HUMAN (33-174): 3.9e-15: 78.4: 25.34