HitPredict

Interactor 1: LRP1 (Q07954)
Prolow-density lipoprotein receptor-related protein 1 (LRP-1) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD antigen CD91) [Cleaved into: Low-density lipoprotein receptor-related protein 1 85 kDa subunit (LRP-85); Low-density lipoprotein receptor-related protein 1 515 kDa subunit (LRP-515); Low-density lipoprotein receptor-related protein 1 intracellular domain (LRPICD)]
Gene: LRP1

Interactor 2: JIP2 (Q13387)
C-Jun-amino-terminal kinase-interacting protein 2 (JIP-2) (JNK-interacting protein 2) (Islet-brain-2) (IB-2) (JNK MAP kinase scaffold protein 2) (Mitogen-activated protein kinase 8-interacting protein 2)
Gene: MAPK8IP2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.46	0.60	0.527

Property	Details
Experiments	10827173
Identification Methods	two hybrid, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001540 - amyloid-beta binding GO:0044877 - protein-containing complex binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 4544 Hs			1 824
+	Mm
		1362475 LRP1_MOUSE (24-4544): 0: 3498: 98.08		JIP2_MOUSE (1-824): 1.39e-154: 474: 84.87
+	Hs
		1060889 LRP1_HUMAN (24-4544): 0: 3504: 100.00		ANS1B_HUMAN (536-809): 9.83e-53: 201: 15.52
+	Hs
		1060927 LRP1_HUMAN (24-4544): 0: 3504: 100.00		GULP1_HUMAN (663-814): 7.51e-43: 159: 24.84
+	Mm
		1362476 LRP1_MOUSE (24-4544): 0: 3498: 98.08		JIP1_MOUSE (13-351): 2.24e-18: 92.2: 19.09
+	Hs
		1060938 LRP1_HUMAN (24-4544): 0: 3504: 100.00		JIP1_HUMAN (13-355): 1.57e-16: 86: 18.54
+	Mm
		59789 LRP2_MOUSE (2-278): 1.03e-10: 71: 18.56		JIP2_MOUSE (1-824): 1.39e-154: 474: 84.87
+	Mm
		73134 B1AXJ3_MOUSE (4275-4499): 5.99e-10: 67.9: 11.72		JIP2_MOUSE (1-824): 1.39e-154: 474: 84.87
+	Hs
		1022604 LRP2_HUMAN (2-286): 2.25e-10: 69.9: 13.86		JIP2_HUMAN (1-824): 2.75e-152: 468: 100.00
+	Hs
		1103687 LRP8_HUMAN (4189-4499): 2.45e-10: 69.5: 12.99		JIP2_HUMAN (1-824): 2.75e-152: 468: 100.00
+	Hs
		1022627 LRP2_HUMAN (2-286): 2.25e-10: 69.9: 13.86		ANS1B_HUMAN (536-809): 9.83e-53: 201: 15.52
+	Dm
		451851 NOTCH_DROME (73-314): 9.31e-13: 77.6: 12.68		Q9VCM6_DROME (47-809): 1.83e-43: 173: 13.43
+	Hs
		1022618 LRP2_HUMAN (2-286): 2.25e-10: 69.9: 13.86		ARH_HUMAN (660-809): 1.52e-40: 153: 18.42
+	Hs
		376509 LDLR_HUMAN (4098-4307): 8.05e-10: 67.6: 13.72		ARH_HUMAN (660-809): 1.52e-40: 153: 18.42
+	Mm
		59785 LRP2_MOUSE (2-278): 1.03e-10: 71: 18.56		ARH_MOUSE (660-809): 2.35e-38: 147: 19.08
+	Rn
		92834 LRP2_RAT (2-284): 6.99e-12: 74.9: 14.37		ARH_RAT (660-809): 3.89e-36: 140: 19.08
+	Mm
		1354131 LRP4_MOUSE (4235-4537): 3.72e-13: 78.7: 13.42		JIP1_MOUSE (13-351): 2.24e-18: 92.2: 19.09
+	Mm
		59790 LRP2_MOUSE (2-278): 1.03e-10: 71: 18.56		JIP1_MOUSE (13-351): 2.24e-18: 92.2: 19.09
+	Mm
		73136 B1AXJ3_MOUSE (4275-4499): 5.99e-10: 67.9: 11.72		JIP1_MOUSE (13-351): 2.24e-18: 92.2: 19.09
+	Hs
		1022669 LRP2_HUMAN (2-286): 2.25e-10: 69.9: 13.86		JIP1_HUMAN (13-355): 1.57e-16: 86: 18.54
+	Hs
		1120590 LRP8_HUMAN (4189-4499): 2.45e-10: 69.5: 12.99		JIP1_HUMAN (13-355): 1.57e-16: 86: 18.54