HitPredict

Interactor 1: LRP1 (Q91ZX7)
Prolow-density lipoprotein receptor-related protein 1 (LRP-1) (Alpha-2-macroglobulin receptor) (A2MR) (CD antigen CD91) [Cleaved into: Low-density lipoprotein receptor-related protein 1 85 kDa subunit (LRP-85); Low-density lipoprotein receptor-related protein 1 515 kDa subunit (LRP-515); Low-density lipoprotein receptor-related protein 1 intracellular domain (LRPICD)]
Gene: LRP1

Interactor 2: JIP1 (Q9WVI9)
C-Jun-amino-terminal kinase-interacting protein 1 (JIP-1) (JNK-interacting protein 1) (Islet-brain-1) (IB-1) (JNK MAP kinase scaffold protein 1) (Mitogen-activated protein kinase 8-interacting protein 1)
Gene: Mapk8ip1

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.42	0.60	0.506

Property	Details
Experiments	10827173
Identification Methods	two hybrid, pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005886 - plasma membrane GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 4545 Mm			1 707
+	Mm
		1362475 LRP1_MOUSE (19-4545): 0: 3504: 100.00		JIP2_MOUSE (21-256): 1e-44: 174: 29.46
+	Mm
		1440826 LRP1B_MOUSE (22-303): 2.63e-10: 69.5: 17.35		JIP1_MOUSE (1-707): 0: 783: 100.00
+	Mm
		73136 B1AXJ3_MOUSE (4120-4370): 3.27e-10: 68.7: 13.51		JIP1_MOUSE (1-707): 0: 783: 100.00
+	Mm
		1363389 LRP8_MOUSE (25-285): 1.89e-09: 66.4: 17.54		JIP1_MOUSE (1-707): 0: 783: 100.00
+	Mm
		1354131 LRP4_MOUSE (2837-3048): 3.38e-09: 65.6: 21.76		JIP1_MOUSE (1-707): 0: 783: 100.00
+	Hs
		1120590 LRP8_HUMAN (1055-1338): 1.14e-10: 70.3: 19.34		JIP1_HUMAN (1-707): 0: 730: 92.42
+	Hs
		1036650 LRP8_HUMAN (1055-1338): 1.14e-10: 70.3: 19.34		APBA1_HUMAN (70-698): 4.3e-126: 396: 16.54
+	Hs
		1022627 LRP2_HUMAN (4230-4522): 5.98e-09: 65.3: 13.74		ANS1B_HUMAN (419-696): 2.28e-61: 225: 18.51
+	Hs
		376585 EGF_HUMAN (4349-4497): 4.57e-09: 65.3: 13.13		SHC1_HUMAN (413-696): 5.58e-57: 205: 15.02
+	Hs
		1103687 LRP8_HUMAN (1055-1338): 1.14e-10: 70.3: 19.34		JIP2_HUMAN (21-266): 8.55e-45: 174: 32.30
+	Mm
		1424407 LRP1B_MOUSE (22-303): 2.63e-10: 69.5: 17.35		JIP2_MOUSE (21-256): 1e-44: 174: 29.46
+	Mm
		73134 B1AXJ3_MOUSE (4120-4370): 3.27e-10: 68.7: 13.51		JIP2_MOUSE (21-256): 1e-44: 174: 29.46
+	Mm
		1363388 LRP8_MOUSE (25-285): 1.89e-09: 66.4: 17.54		JIP2_MOUSE (21-256): 1e-44: 174: 29.46
+	Hs
		1022604 LRP2_HUMAN (4230-4522): 5.98e-09: 65.3: 13.74		JIP2_HUMAN (21-266): 8.55e-45: 174: 32.30
+	Hs
		857377 NOTC1_HUMAN (2840-3059): 1.46e-12: 77.2: 10.37		NUMB_HUMAN (524-700): 2.75e-40: 159: 18.38
+	Hs
		269764 LRP8_HUMAN (1055-1338): 1.14e-10: 70.3: 19.34		CAPON_HUMAN (541-703): 1.09e-36: 146: 20.69
+	Hs
		269758 LRP2_HUMAN (4230-4522): 5.98e-09: 65.3: 13.74		CAPON_HUMAN (541-703): 1.09e-36: 146: 20.69
+	Hs
		376509 LDLR_HUMAN (4018-4371): 2.73e-09: 65.6: 10.11		ARH_HUMAN (543-702): 9.93e-38: 144: 19.14
+	Hs
		1022618 LRP2_HUMAN (4230-4522): 5.98e-09: 65.3: 13.74		ARH_HUMAN (543-702): 9.93e-38: 144: 19.14
+	Rn
		92834 LRP2_RAT (3697-4287): 4.14e-09: 65.6: 12.89		ARH_RAT (527-692): 2.01e-34: 135: 17.54