HitPredict

Interactor 1: LRP1 (Q07954)
Prolow-density lipoprotein receptor-related protein 1 (LRP-1) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD antigen CD91) [Cleaved into: Low-density lipoprotein receptor-related protein 1 85 kDa subunit (LRP-85); Low-density lipoprotein receptor-related protein 1 515 kDa subunit (LRP-515); Low-density lipoprotein receptor-related protein 1 intracellular domain (LRPICD)]
Gene: LRP1

Interactor 2: APOA5 (Q6Q788)
Apolipoprotein A-V (Apo-AV) (ApoA-V) (Apolipoprotein A5) (Regeneration-associated protein 3)
Gene: APOA5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	17326667
Identification Methods	surface plasmon resonance
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005769 - early endosome GO:0005794 - Golgi apparatus GO:0070325 - lipoprotein particle receptor binding
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 4544 Hs			1 366
+	Hs
		387414 LRP1_HUMAN (24-4544): 0: 3504: 100.00		APOE_HUMAN (77-352): 3.92e-10: 62.2: 17.02
+	Hs
		1246205 SORL_HUMAN (1080-1344): 6.87e-10: 68.3: 13.65		APOA5_HUMAN (1-366): 1.06e-107: 321: 100.00
+	Hs
		387407 VLDLR_HUMAN (27-294): 2.66e-11: 72.6: 17.73		APOE_HUMAN (77-352): 3.92e-10: 62.2: 17.02
+	Hs
		387408 LRP2_HUMAN (2-286): 2.25e-10: 69.9: 13.86		APOE_HUMAN (77-352): 3.92e-10: 62.2: 17.02
+	Hs
		387419 LRP8_HUMAN (4189-4499): 2.45e-10: 69.5: 12.99		APOE_HUMAN (77-352): 3.92e-10: 62.2: 17.02
+	Hs
		387446 SORL_HUMAN (1080-1344): 6.87e-10: 68.3: 13.65		APOE_HUMAN (77-352): 3.92e-10: 62.2: 17.02
+	Hs
		376456 LDLR_HUMAN (4098-4307): 8.05e-10: 67.6: 13.72		APOE_HUMAN (77-352): 3.92e-10: 62.2: 17.02