HitPredict

Interactor 1: SRSF4 (Q08170)
Serine/arginine-rich splicing factor 4 (Pre-mRNA-splicing factor SRP75) (SRP001LB) (Splicing factor, arginine/serine-rich 4)
Gene: SRSF4

Interactor 2: BRX1 (Q8TDN6)
Ribosome biogenesis protein BRX1 homolog (Brix domain-containing protein 2)
Gene: BRIX1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 494 Hs			1 353
+	Hs
		1099451 SRSF6_HUMAN (1-180): 4.54e-52: 181: 78.50		BRX1_HUMAN (1-353): 6.15e-146: 418: 100.00
+	Hs
		1099177 SRSF5_HUMAN (3-256): 1.26e-49: 172: 53.85		BRX1_HUMAN (1-353): 6.15e-146: 418: 100.00
+	Sc
		791120 NOP4_YEAST (1-492): 5.12e-54: 194: 11.63		BRX1_YEAST (40-305): 1.93e-92: 279: 45.32
+	Hs
		1061093 SRSF1_HUMAN (3-166): 2.37e-57: 192: 41.42		IMP4_HUMAN (2-272): 6.95e-91: 275: 17.56
+	Hs
		1099473 SRSF6_HUMAN (1-180): 4.54e-52: 181: 78.50		IMP4_HUMAN (2-272): 6.95e-91: 275: 17.56
+	Hs
		1062078 SRSF4_HUMAN (1-468): 4.58e-48: 174: 100.00		IMP4_HUMAN (2-272): 6.95e-91: 275: 17.56
+	Hs
		1099201 SRSF5_HUMAN (3-256): 1.26e-49: 172: 53.85		IMP4_HUMAN (2-272): 6.95e-91: 275: 17.56
+	Hs
		1061157 SRSF1_HUMAN (3-166): 2.37e-57: 192: 41.42		RPF1_HUMAN (13-269): 1.37e-72: 230: 20.83
+	Hs
		1099542 SRSF6_HUMAN (1-180): 4.54e-52: 181: 78.50		RPF1_HUMAN (13-269): 1.37e-72: 230: 20.83
+	Hs
		1099259 SRSF5_HUMAN (3-256): 1.26e-49: 172: 53.85		RPF1_HUMAN (13-269): 1.37e-72: 230: 20.83
+	Sc
		791055 NOP4_YEAST (1-492): 5.12e-54: 194: 11.63		RPF1_YEAST (4-269): 5.63e-62: 201: 15.33
+	Hs
		1061150 SRSF1_HUMAN (3-166): 2.37e-57: 192: 41.42		RPF2_HUMAN (106-247): 1.01e-31: 122: 22.88
+	Hs
		1099537 SRSF6_HUMAN (1-180): 4.54e-52: 181: 78.50		RPF2_HUMAN (106-247): 1.01e-31: 122: 22.88
+	Hs
		1099253 SRSF5_HUMAN (3-256): 1.26e-49: 172: 53.85		RPF2_HUMAN (106-247): 1.01e-31: 122: 22.88
+	Hs
		1061168 SRSF1_HUMAN (3-166): 2.37e-57: 192: 41.42		SSF1_HUMAN (54-228): 2.88e-21: 96.4: 15.22
+	Sc
		791053 NOP4_YEAST (1-492): 5.12e-54: 194: 11.63		SSF1_YEAST (39-230): 7.39e-18: 86.4: 14.88
+	Hs
		1099559 SRSF6_HUMAN (1-180): 4.54e-52: 181: 78.50		SSF1_HUMAN (54-228): 2.88e-21: 96.4: 15.22
+	Hs
		1099267 SRSF5_HUMAN (3-256): 1.26e-49: 172: 53.85		SSF1_HUMAN (54-228): 2.88e-21: 96.4: 15.22
+	Sc
		782313 NOP4_YEAST (1-492): 5.12e-54: 194: 11.63		RPF2_YEAST (71-267): 1.62e-13: 72.5: 19.56
+	Sc
		676723 GBP2_YEAST (4-201): 2.7e-25: 109: 20.19		SSF1_YEAST (39-230): 7.39e-18: 86.4: 14.88