Protein: RPF1
Ribosome production factor 1 (Brix domain-containing protein 5) (Ribosome biogenesis protein RPF1)

Gene: RPF1
Organism: Homo sapiens
Interactions: 134
UniProt ID: Q9H9Y2

Gene Ontology (top 5):
GO:0000460 - maturation of 5.8S rRNA
GO:0000470 - maturation of LSU-rRNA
GO:0003723 - RNA binding
GO:0005730 - nucleolus
GO:0030687 - preribosome, large subunit precursor

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

970110

RS16
Small ribosomal subunit protein uS9

2

2

High-throughput

0.811

High

1417563

MAK16
Protein MAK16 homolog

2

5

High-throughput

0.811

High

290742

SURF6
Surfeit locus protein 6

1

2

High-throughput

0.691

High

615991

RL17
Large ribosomal subunit protein uL22

1

3

High-throughput

0.691

High

1437306

RL36
Large ribosomal subunit protein eL36

1

3

High-throughput

0.691

High

447462

NPM
Nucleophosmin

4

5

High-throughput

0.691

High

898828

RL14
Large ribosomal subunit protein eL14

3

3

High-throughput

0.667

High

1418593

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

3

7

High-throughput

0.667

High

208387

RRP8
Ribosomal RNA-processing protein 8

2

2

High-throughput

0.628

High

961845

RL37A
Large ribosomal subunit protein eL43

2

4

High-throughput

0.628

High

977088

CNBP
CCHC-type zinc finger nucleic acid binding protein

2

2

High-throughput

0.628

High

984549

RL30
Large ribosomal subunit protein eL30

2

3

High-throughput

0.628

High

1037650

RL18A
Large ribosomal subunit protein eL20

2

4

High-throughput

0.628

High

1137161

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

2

1

High-throughput

0.628

High

1348851

ZCRB1
Zinc finger CCHC-type and RNA-binding motif-containing protein 1

2

4

High-throughput

0.628

High

1437303

RL26L
Ribosomal protein uL24-like

2

6

High-throughput

0.611

High

1313151

ZC3H3
Zinc finger CCCH domain-containing protein 3

3

2

High-throughput

0.609

High

340532

ZBT11
Zinc finger and BTB domain-containing protein 11

2

0

High-throughput

0.602

High

288777

NPM3
Nucleoplasmin-3

2

5

High-throughput

0.601

High

950407

KR107
Keratin-associated protein 10-7

2

2

High-throughput

0.590

High

282905

Z324A
Zinc finger protein 324A

2

2

High-throughput

0.574

High

1230904

Z324B
Zinc finger protein 324B

2

1

High-throughput

0.574

High

1397746

MAGBA
Melanoma-associated antigen B10

2

5

High-throughput

0.574

High

1398076

ZN512
Zinc finger protein 512

2

1

High-throughput

0.574

High

1437296

H2AW
Core histone macro-H2A.2

2

6

High-throughput

0.574

High

228751

U3IP2
U3 small nucleolar RNA-interacting protein 2

1

2

High-throughput

0.536

High

287143

PRKRA
Interferon-inducible double-stranded RNA-dependent protein kinase activator A

1

14

High-throughput

0.536

High

301214

RL1D1
Ribosomal L1 domain-containing protein 1

1

9

High-throughput

0.536

High

428991

RLA0
Large ribosomal subunit protein uL10

1

5

High-throughput

0.536

High

521950

H14
Histone H1.4

1

10

High-throughput

0.536

High

586893

RS2
Small ribosomal subunit protein uS5

1

3

High-throughput

0.536

High

595875

H13
Histone H1.3

1

10

High-throughput

0.536

High

596364

H12
Histone H1.2

1

10

High-throughput

0.536

High

686440

RL13
Large ribosomal subunit protein eL13

1

4

High-throughput

0.536

High

785462

RL4
Large ribosomal subunit protein uL4

1

4

High-throughput

0.536

High

809851

RS19
Small ribosomal subunit protein eS19

1

4

High-throughput

0.536

High

824366

RL13A
Large ribosomal subunit protein uL13

1

3

High-throughput

0.536

High

833197

MNDA
Myeloid cell nuclear differentiation antigen

1

5

High-throughput

0.536

High

842541

RL35
Large ribosomal subunit protein uL29

1

1

High-throughput

0.536

High

854313

KI67
Proliferation marker protein Ki-67

1

1

High-throughput

0.536

High

855222

NOP2
28S rRNA

1

8

High-throughput

0.536

High

859075

RL27A
Large ribosomal subunit protein uL15

1

1

High-throughput

0.536

High

860008

RL28
Large ribosomal subunit protein eL28

1

1

High-throughput

0.536

High

860957

RS10
Small ribosomal subunit protein eS10

1

3

High-throughput

0.536

High

905158

MECP2
Methyl-CpG-binding protein 2

1

1

High-throughput

0.536

High

960896

RL15
Large ribosomal subunit protein eL15

1

3

High-throughput

0.536

High

975952

RL7A
Large ribosomal subunit protein eL8

1

6

High-throughput

0.536

High

978734

RL23A
Large ribosomal subunit protein uL23

1

3

High-throughput

0.536

High

979252

RS6
Small ribosomal subunit protein eS6

1

4

High-throughput

0.536

High

984998

RL31
Large ribosomal subunit protein eL31

1

4

High-throughput

0.536

High

985343

RL10A
Large ribosomal subunit protein uL1

1

9

High-throughput

0.536

High

985893

RL11
Large ribosomal subunit protein uL5

1

3

High-throughput

0.536

High

986221

RL8
Large ribosomal subunit protein uL2

1

4

High-throughput

0.536

High

994805

YBOX1
Y-box-binding protein 1

1

5

High-throughput

0.536

High

1008894

RED1
Double-stranded RNA-specific editase 1

1

8

High-throughput

0.536

High

1011903

RT05
Small ribosomal subunit protein uS5m

1

3

High-throughput

0.536

High

1057911

RL18
Large ribosomal subunit protein eL18

1

2

High-throughput

0.536

High

1061157

SRSF1
Serine/arginine-rich splicing factor 1

1

12

High-throughput

0.536

High

1099259

SRSF5
Serine/arginine-rich splicing factor 5

1

12

High-throughput

0.536

High

1099542

SRSF6
Serine/arginine-rich splicing factor 6

1

15

High-throughput

0.536

High

1112181

KRR1
KRR1 small subunit processome component homolog

1

5

High-throughput

0.536

High

1245504

CC137
Coiled-coil domain-containing protein 137

1

1

High-throughput

0.536

High

1247291

WDR74
WD repeat-containing protein 74

1

5

High-throughput

0.536

High

1275683

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

3

High-throughput

0.536

High

1361765

DGCR8
Microprocessor complex subunit DGCR8

1

2

High-throughput

0.536

High

1370114

RENT1
Regulator of nonsense transcripts 1

1

2

High-throughput

0.536

High

1395822

ZC3HA
Zinc finger CCCH domain-containing protein 10

1

1

High-throughput

0.536

High

1409845

RBM4B
RNA-binding protein 4B

1

4

High-throughput

0.536

High

1410736

MBB1A
Myb-binding protein 1A

1

1

High-throughput

0.536

High

1437290

LN28A
Protein lin-28 homolog A

1

7

High-throughput

0.536

High

1437292

ABC3C
DNA dC->dU-editing enzyme APOBEC-3C

1

1

High-throughput

0.536

High

1437294

STAU2
Double-stranded RNA-binding protein Staufen homolog 2

1

14

High-throughput

0.536

High

1437295

LYAR
Cell growth-regulating nucleolar protein

1

2

High-throughput

0.536

High

1437299

PURG
Purine-rich element-binding protein gamma

1

2

High-throughput

0.536

High

1437300

ZN346
Zinc finger protein 346

1

2

High-throughput

0.536

High

1437302

ABT1
Activator of basal transcription 1

1

2

High-throughput

0.536

High

1437305

YBOX2
Y-box-binding protein 2

1

5

High-throughput

0.536

High

788781

SRP14
Signal recognition particle 14 kDa protein

1

0

High-throughput

0.513

High

191811

MAGB2
Melanoma-associated antigen B2

1

5

High-throughput

0.489

High

338968

CBX6
Chromobox protein homolog 6

1

1

High-throughput

0.489

High

391468

FRIL
Ferritin light chain

1

1

High-throughput

0.489

High

502544

H2A1
Histone H2A type 1

1

4

High-throughput

0.489

High

517822

GLI4
Zinc finger protein GLI4

1

1

High-throughput

0.489

High

1037379

H11
Histone H1.1

1

10

High-throughput

0.489

High

1127499

FGFP1
Fibroblast growth factor-binding protein 1

1

2

High-throughput

0.489

High

1178092

RN151
RING finger protein 151

1

2

High-throughput

0.489

High

1316139

H18
Histone H1.8

1

1

High-throughput

0.489

High

1370540

FGF13
Fibroblast growth factor 13

1

1

High-throughput

0.489

High

1390618

NEIL1
Endonuclease 8-like 1

1

2

High-throughput

0.489

High

1395709

ZN668
Zinc finger protein 668

1

1

High-throughput

0.489

High

1398131

CC140
Coiled-coil domain-containing protein 140

1

1

High-throughput

0.489

High

1437304

SRPK3
SRSF protein kinase 3

1

3

High-throughput

0.489

High

346353

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

14

High-throughput

0.479

High

373181

MYC
Myc proto-oncogene protein

1

3

High-throughput

0.479

High

693989

RL10
Large ribosomal subunit protein uL16

1

4

High-throughput

0.479

High

810391

RL3
Large ribosomal subunit protein uL3

1

4

High-throughput

0.479

High

960257

RL26
Large ribosomal subunit protein uL24

1

6

High-throughput

0.479

High

1161679

IF16
Gamma-interferon-inducible protein 16

1

5

High-throughput

0.479

High

1215838

RC3H1
Roquin-1

1

3

High-throughput

0.479

High

1290736

ZCH18
Zinc finger CCCH domain-containing protein 18

1

1

High-throughput

0.479

High

1437297

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

3

High-throughput

0.479

High

1437298

NOL12
Nucleolar protein 12

1

1

High-throughput

0.479

High

881316

FAS
Fatty acid synthase

1

0

High-throughput

0.460

High

1006725

SRPK2
SRSF protein kinase 2

1

4

High-throughput

0.445

High

1130461

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

6

High-throughput

0.445

High

1437293

RBM12
RNA-binding protein 12

1

7

High-throughput

0.445

High

157867

CTRO
Citron Rho-interacting kinase

1

2

High-throughput

0.437

High

589724

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.437

High

696544

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

769212

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

1017220

H33
Histone H3.3

1

3

High-throughput

0.437

High

1067728

EP300
Histone acetyltransferase p300

1

1

High-throughput

0.437

High

1367309

ESR2
Estrogen receptor beta

1

2

High-throughput

0.437

High

1385627

DCPS
m7GpppX diphosphatase

1

1

High-throughput

0.437

High

1402310

RANB9
Ran-binding protein 9

1

2

High-throughput

0.437

High

1437301

HECD1
E3 ubiquitin-protein ligase HECTD1

1

2

High-throughput

0.437

High

818768

CAPG
Macrophage-capping protein

1

0

High-throughput

0.426

High

58938

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

1

High-throughput

0.407

High

1387894

PABP5
Polyadenylate-binding protein 5

1

2

High-throughput

0.407

High

1128683

ZN460
Zinc finger protein 460

2

0

High-throughput

0.328

High

1226650

E4F1
Transcription factor E4F1

2

0

High-throughput

0.328

High

137485

HMGN4
High mobility group nucleosome-binding domain-containing protein 4

1

0

High-throughput

0.279

Low

634644

LMNB1
Lamin-B1

1

0

High-throughput

0.279

Low

1281479

ZN467
Zinc finger protein 467

1

0

High-throughput

0.279

Low

1386441

ZN689
Zinc finger protein 689

1

0

High-throughput

0.279

Low

1437291

DBLOH
Diablo IAP-binding mitochondrial protein

1

0

High-throughput

0.279

Low

363875

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.249

Low

937920

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.249

Low

1108166

SQSTM
Sequestosome-1

1

0

High-throughput

0.249

Low

1156863

E2F4
Transcription factor E2F4

1

0

High-throughput

0.249

Low

1380757

RL36L
Ribosomal protein eL42-like

1

0

High-throughput

0.249

Low

1292650

CCD25
Coiled-coil domain-containing protein 25

1

0

High-throughput

0.232

Low

1395292

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.232

Low

1395582

PDLI2
PDZ and LIM domain protein 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025