HitPredict

Interactor 1: RPN8 (Q08723)
26S proteasome regulatory subunit RPN8
Gene: RPN8

Interactor 2: RPN6 (Q12377)
26S proteasome regulatory subunit RPN6 (Proteasome non-ATPase subunit 4)
Gene: RPN6

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.95 1.00 0.976

The method score is based on:

Property Details
Experiments 11805826, 14759368, 23911091, 24412063, 15102831, 9741626, 16554755, 16429126, 18467557, 37968396, 31848235
Identification Methods tandem affinity purification, affinity chromatography technology, biochemical, protein complementation assay, cross-linking study, dihydrofolate reductase reconstruction, anti tag coimmunoprecipitation
Interaction Type physical association, association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains MitMem_reg~PCI, MitMem_reg~RPN6_C_helix
Common GO terms GO:0000502 - proteasome complex
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0008541 - proteasome regulatory particle, lid subcomplex
GO:0034515 - proteasome storage granule
GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 338
Sc

1 434
+ Dm
+ Hs
+ Hs
+ Hs
+ Mm
+ Dm
+ Dm
+ Hs
+ Mm
+ Mm
+ Hs
+ Hs
+ Mm
+ Sp
+ Dm
+ Dm
+ Dm
+ Dm
+ Ce
+ Dm

Service provided by Combinatics, Japan

Last updated: 11Aug2025