HitPredict

Interactor 1: CDC37 (Q16543)
Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed]
Gene: CDC37

Interactor 2: SGK3 (Q96BR1)
Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Cytokine-independent survival kinase) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid-regulated kinase-like)
Gene: SGK3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	33961781, 32707033
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	CDC37_M~Pkinase, CDC37_N~Pkinase
Common GO terms	GO:0005829 - cytosol
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 378 Hs			1 496
+	Hs
		1083052 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		AKT3_HUMAN (20-493): 9.6e-167: 481: 38.27
+	Hs
		681873 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		AKT1_HUMAN (20-491): 1.46e-165: 478: 36.48
+	Hs
		682179 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		AKT2_HUMAN (20-490): 5.54e-165: 477: 36.63
+	Hs
		117008 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		SGK1_HUMAN (86-495): 2e-162: 468: 66.34
+	Hs
		969088 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		KPCE_HUMAN (1-487): 1.02e-152: 454: 30.26
+	Hs
		1082996 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		SGK2_HUMAN (129-495): 2.69e-152: 440: 66.76
+	Hs
		566401 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		KPCA_HUMAN (42-490): 3.95e-147: 438: 33.55
+	Hs
		784018 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		KPCI_HUMAN (14-490): 3.77e-147: 435: 32.72
+	Hs
		1083029 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		KS6B2_HUMAN (122-491): 2.13e-147: 432: 41.87
+	Hs
		850660 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		KS6A3_HUMAN (48-466): 8.02e-109: 341: 23.72
+	Hs
		1073425 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		KS6A1_HUMAN (47-423): 1.85e-95: 306: 27.32
+	Hs
		983850 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		KPCZ_HUMAN (161-458): 1.09e-90: 290: 45.60
+	Hs
		1083040 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		KS6A6_HUMAN (162-419): 2.41e-87: 285: 27.88
+	Dm
		954662 CDC37_DROME (1-351): 1.28e-126: 371: 52.54		P91656_DROME (132-494): 4.42e-90: 289: 42.43
+	Dm
		1096957 CDC37_DROME (1-351): 1.28e-126: 371: 52.54		Q94533_DROME (132-494): 7.69e-91: 287: 42.43