HitPredict

Interactor 1: RBBP7 (Q16576)
Histone-binding protein RBBP7 (Histone acetyltransferase type B subunit 2) (Nucleosome-remodeling factor subunit RBAP46) (Retinoblastoma-binding protein 7) (RBBP-7) (Retinoblastoma-binding protein p46)
Gene: RBBP7

Interactor 2: PHF19 (Q5T6S3)
PHD finger protein 19 (Polycomb-like protein 3) (hPCL3)
Gene: PHF19

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	23104054, 27705803, 33961781
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006355 - regulation of DNA-templated transcription GO:0035098 - ESC/E(Z) complex
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 425 Hs			1 580
+	Hs
		1083441 RBBP7_HUMAN (1-425): 2.38e-115: 345: 100.00		MTF2_HUMAN (39-578): 0: 631: 46.24
+	Hs
		997758 RBBP4_HUMAN (1-209): 1.59e-39: 148: 12.72		PHF19_HUMAN (1-580): 0: 818: 100.00
+	Hs
		197993 RBBP7_HUMAN (1-425): 2.38e-115: 345: 100.00		PHF1_HUMAN (39-576): 0: 618: 41.39
+	Hs
		997966 RBBP4_HUMAN (1-209): 1.59e-39: 148: 12.72		MTF2_HUMAN (39-578): 0: 631: 46.24
+	Mm
		970679 RBBP4_MOUSE (1-209): 1.59e-39: 148: 12.72		MTF2_MOUSE (17-578): 0: 622: 45.69
+	Hs
		197973 RBBP4_HUMAN (1-209): 1.59e-39: 148: 12.72		PHF1_HUMAN (39-576): 0: 618: 41.39
+	Dm
		1097854 CAF1_DROME (1-209): 8.04e-42: 154: 13.16		PCL_DROME (40-462): 2.4e-146: 450: 26.62
+	Hs
		1202784 WDR5B_HUMAN (1-254): 1.38e-58: 196: 14.83		ASH2L_HUMAN (186-574): 7.89e-106: 333: 14.60
+	Dm
		1276839 WDS_DROME (212-422): 1.48e-43: 157: 19.91		ASH2_DROME (186-574): 4.5e-117: 360: 16.17
+	Hs
		903577 WDR5_HUMAN (311-425): 1.28e-17: 85.2: 22.61		ASH2L_HUMAN (186-574): 7.89e-106: 333: 14.60
+	Dm
		1358852 WDS_DROME (212-422): 1.48e-43: 157: 19.91		Q9VJ73_DROME (184-506): 8.91e-70: 241: 17.44
+	Hs
		267794 TAF5L_HUMAN (32-291): 7.24e-42: 157: 16.48		CSR2B_HUMAN (201-415): 7.95e-59: 211: 24.89
+	Hs
		903524 WDR5_HUMAN (311-425): 1.28e-17: 85.2: 22.61		CSR2B_HUMAN (201-415): 7.95e-59: 211: 24.89
+	Mm
		903674 WDR5_MOUSE (311-425): 1.28e-17: 85.2: 22.61		CSR2B_MOUSE (201-415): 1.05e-58: 211: 23.98