HitPredict

Interactor 1: H2B2E (Q16778)
Histone H2B type 2-E (H2B-clustered histone 21) (Histone H2B-GL105) (Histone H2B.q) (H2B/q)
Gene: H2BC21

Interactor 2: HMGX4 (Q9UGU5)
HMG domain-containing protein 4 (HMG box-containing protein 4) (High mobility group protein 2-like 1) (Protein HMGBCG)
Gene: HMGXB4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 126 Hs			1 601
+	Hs
		918757 H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21		HMGX4_HUMAN (1-601): 0: 813: 100.00
+	Hs
		297497 H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00		TOX4_HUMAN (339-528): 4.7e-37: 148: 24.76
+	Hs
		1087228 H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00		PB1_HUMAN (368-514): 1.71e-34: 142: 25.16
+	Hs
		918481 H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21		PB1_HUMAN (368-514): 1.71e-34: 142: 25.16
+	Hs
		707673 H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41		PB1_HUMAN (368-514): 1.71e-34: 142: 25.16
+	Hs
		420830 H2B1J_HUMAN (1-126): 7.8e-54: 166: 99.21		SSRP1_HUMAN (389-478): 6.97e-30: 126: 33.70
+	Hs
		918316 H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21		SSRP1_HUMAN (389-478): 6.97e-30: 126: 33.70
+	Hs
		996694 H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00		SSRP1_HUMAN (389-478): 6.97e-30: 126: 33.70
+	Hs
		996812 H2B1H_HUMAN (1-126): 6.27e-54: 166: 98.41		SSRP1_HUMAN (389-478): 6.97e-30: 126: 33.70
+	Hs
		996768 H2B3B_HUMAN (1-126): 1.01e-51: 161: 96.03		SSRP1_HUMAN (389-478): 6.97e-30: 126: 33.70
+	Hs
		996816 H2B1A_HUMAN (1-126): 3.43e-46: 147: 85.04		SSRP1_HUMAN (389-478): 6.97e-30: 126: 33.70
+	Hs
		449786 H2B1H_HUMAN (1-126): 6.27e-54: 166: 98.41		HMGB1_HUMAN (388-485): 1.57e-24: 103: 30.00
+	Hs
		643302 H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21		HMGB2_HUMAN (405-494): 1.76e-22: 97.6: 35.56
+	Hs
		643380 H2B1H_HUMAN (1-126): 6.27e-54: 166: 98.41		HMGB2_HUMAN (405-494): 1.76e-22: 97.6: 35.56
+	Hs
		643248 H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41		HMGB2_HUMAN (405-494): 1.76e-22: 97.6: 35.56
+	Hs
		241615 H2B1K_HUMAN (1-126): 1.56e-53: 165: 98.41		CIC_HUMAN (362-527): 1.94e-12: 72.6: 25.29
+	Hs
		175767 H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21		HMGB3_HUMAN (411-495): 5.79e-12: 67.2: 21.84
+	Sc
		355756 H2B2_YEAST (3-125): 4.73e-37: 124: 71.55		NHP6B_YEAST (388-479): 1.39e-15: 74.5: 28.72
+	Sc
		355755 H2B2_YEAST (3-125): 4.73e-37: 124: 71.55		NHP6A_YEAST (394-476): 2.15e-14: 71: 29.41
+	Sc
		355313 H2B1_YEAST (3-125): 1.81e-36: 122: 71.55		NHP6A_YEAST (394-476): 2.15e-14: 71: 29.41