HitPredict

Interactor 1: ANK3 (Q12955)
Ankyrin-3 (ANK-3) (Ankyrin-G)
Gene: ANK3

Interactor 2: TTBK1 (Q5TCY1)
Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase)
Gene: TTBK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ank~Pkinase, Ank_2~Pkinase, Ank_4~Pkinase
Common GO terms	GO:0005829 - cytosol GO:0007165 - signal transduction GO:0010628 - positive regulation of gene expression
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 4377 Hs			1 1321
+	Hs
		1091473 ANK3_HUMAN (1-4377): 0: 1969: 100.00		TNIK_HUMAN (34-914): 9.66e-123: 415: 12.82
+	Hs
		1461045 ANR50_HUMAN (1-568): 0: 678: 32.41		TNIK_HUMAN (34-914): 9.66e-123: 415: 12.82
+	Hs
		1030710 ANK2_HUMAN (1-749): 8.42e-153: 540: 33.77		TNIK_HUMAN (34-914): 9.66e-123: 415: 12.82
+	Hs
		592939 ANK1_HUMAN (1-683): 0: 712: 35.52		OBSCN_HUMAN (1-303): 3.15e-43: 176: 12.54
+	Hs
		332460 TNKS1_HUMAN (536-1328): 2.07e-105: 374: 17.65		TNIK_HUMAN (34-914): 9.66e-123: 415: 12.82
+	Hs
		1030655 ANK2_HUMAN (1-749): 8.42e-153: 540: 33.77		OBSCN_HUMAN (1-303): 3.15e-43: 176: 12.54
+	Mm
		109258 ANK3_MOUSE (3995-4376): 7.19e-36: 153: 41.15		TNIK_MOUSE (34-940): 3.97e-126: 424: 12.77
+	Mm
		1013664 ANK2_MOUSE (3417-4374): 6.06e-16: 88.2: 8.97		TNIK_MOUSE (34-940): 3.97e-126: 424: 12.77
+	Hs
		274257 ANR17_HUMAN (48-194): 3.76e-11: 72.4: 34.43		TNIK_HUMAN (34-914): 9.66e-123: 415: 12.82
+	Hs
		274118 ANR17_HUMAN (48-194): 3.76e-11: 72.4: 34.43		KC1A_HUMAN (20-348): 7.36e-116: 367: 31.55