HitPredict

Interactor 1: UBP4 (Q13107)
Ubiquitin carboxyl-terminal hydrolase 4 (EC 3.4.19.12) (Deubiquitinating enzyme 4) (Ubiquitin thioesterase 4) (Ubiquitin-specific-processing protease 4) (Ubiquitous nuclear protein homolog)
Gene: USP4

Interactor 2: UBP21 (Q9UK80)
Ubiquitin carboxyl-terminal hydrolase 21 (EC 3.4.19.12) (Deubiquitinating enzyme 21) (Ubiquitin thioesterase 21) (Ubiquitin-specific-processing protease 21)
Gene: USP21

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	22626734
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	UCH~UCH
Common GO terms	GO:0004843 - cysteine-type deubiquitinase activity GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006508 - proteolysis GO:0016579 - protein deubiquitination and 1 others more... GO:0046872 - metal ion binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 963 Hs			1 565
+	Hs
		1460948 UBP15_HUMAN (1-927): 0: 742: 57.88		UBP21_HUMAN (1-565): 0: 566: 100.00
+	Hs
		288550 UBP15_HUMAN (1-927): 0: 742: 57.88		UBP2_HUMAN (86-564): 3.31e-132: 400: 37.99
+	Hs
		828266 UBP15_HUMAN (1-927): 0: 742: 57.88		UBP8_HUMAN (16-561): 6.33e-124: 392: 24.05
+	Hs
		1258111 UBP15_HUMAN (1-927): 0: 742: 57.88		UBP51_HUMAN (171-558): 1.16e-102: 327: 23.42
+	Hs
		1094528 UBP4_HUMAN (1-963): 0: 900: 100.00		UBP4_HUMAN (414-556): 5.22e-25: 112: 39.73
+	Hs
		1094663 UBP4_HUMAN (1-963): 0: 900: 100.00		UBP15_HUMAN (405-556): 3.3e-25: 112: 41.29
+	Hs
		1460946 UBP20_HUMAN (252-962): 2.05e-108: 359: 19.75		UBP21_HUMAN (1-565): 0: 566: 100.00
+	Hs
		1353436 UBP33_HUMAN (243-962): 1.23e-104: 349: 18.76		UBP21_HUMAN (1-565): 0: 566: 100.00
+	Hs
		1491395 UBP15_HUMAN (1-927): 0: 742: 57.88		UBP15_HUMAN (405-556): 3.3e-25: 112: 41.29
+	Mm
		1341662 UBP15_MOUSE (1-927): 0: 739: 57.46		UBP15_MOUSE (405-556): 7.82e-25: 111: 40.65
+	Hs
		907405 UBP11_HUMAN (6-937): 0: 727: 44.49		UBP4_HUMAN (414-556): 5.22e-25: 112: 39.73
+	Hs
		907638 UBP11_HUMAN (6-937): 0: 727: 44.49		UBP15_HUMAN (405-556): 3.3e-25: 112: 41.29
+	Hs
		288538 UBP2_HUMAN (618-928): 2.38e-65: 233: 24.36		UBP21_HUMAN (1-565): 0: 566: 100.00
+	Hs
		828259 UBP8_HUMAN (546-926): 5.42e-62: 231: 21.88		UBP21_HUMAN (1-565): 0: 566: 100.00
+	Hs
		828180 UBP8_HUMAN (546-926): 5.42e-62: 231: 21.88		UBP8_HUMAN (16-561): 6.33e-124: 392: 24.05
+	Hs
		322926 UBP19_HUMAN (183-937): 3.28e-146: 469: 30.87		UBP4_HUMAN (414-556): 5.22e-25: 112: 39.73
+	Hs
		1490806 UBP20_HUMAN (252-962): 2.05e-108: 359: 19.75		UBP15_HUMAN (405-556): 3.3e-25: 112: 41.29
+	Hs
		1353440 UBP33_HUMAN (243-962): 1.23e-104: 349: 18.76		UBP15_HUMAN (405-556): 3.3e-25: 112: 41.29