HitPredict

Interactor 1: ADAM9 (Q13443)
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM 9) (EC 3.4.24.-) (Cellular disintegrin-related protein) (Meltrin-gamma) (Metalloprotease/disintegrin/cysteine-rich protein 9) (Myeloma cell metalloproteinase)
Gene: ADAM9

Interactor 2: SNX33 (Q8WV41)
Sorting nexin-33 (SH3 and PX domain-containing protein 3)
Gene: SNX33

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	25825872
Identification Methods	phage display
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0051044 - positive regulation of membrane protein ectodomain proteolysis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 819 Hs			1 574
+	Hs
		1105794 ADAM9_HUMAN (1-819): 0: 662: 100.00		SNX9_HUMAN (1-571): 1.4e-140: 421: 34.18
+	Hs
		1105762 ADAM9_HUMAN (1-819): 0: 662: 100.00		SNX18_HUMAN (1-491): 6.4e-119: 367: 45.84
+	Hs
		209905 ADA12_HUMAN (26-815): 7.07e-166: 505: 35.50		SNX33_HUMAN (1-574): 1.53e-158: 467: 100.00
+	Hs
		1005383 ADAM8_HUMAN (18-814): 4.69e-166: 503: 30.63		SNX33_HUMAN (1-574): 1.53e-158: 467: 100.00
+	Hs
		1357696 ADA19_HUMAN (8-814): 2.49e-164: 503: 31.73		SNX33_HUMAN (1-574): 1.53e-158: 467: 100.00
+	Hs
		209916 ADA12_HUMAN (26-815): 7.07e-166: 505: 35.50		SNX9_HUMAN (1-571): 1.4e-140: 421: 34.18
+	Hs
		1005387 ADAM8_HUMAN (18-814): 4.69e-166: 503: 30.63		SNX9_HUMAN (1-571): 1.4e-140: 421: 34.18
+	Hs
		1429276 ADA19_HUMAN (8-814): 2.49e-164: 503: 31.73		SNX9_HUMAN (1-571): 1.4e-140: 421: 34.18
+	Hs
		1105817 ADA15_HUMAN (30-804): 3.62e-138: 432: 31.10		SNX33_HUMAN (1-574): 1.53e-158: 467: 100.00
+	Hs
		1005385 ADAM8_HUMAN (18-814): 4.69e-166: 503: 30.63		SNX18_HUMAN (1-491): 6.4e-119: 367: 45.84
+	Hs
		1105838 ADA15_HUMAN (30-804): 3.62e-138: 432: 31.10		SNX9_HUMAN (1-571): 1.4e-140: 421: 34.18
+	Hs
		1401304 ATS1_HUMAN (38-661): 3.96e-103: 342: 20.42		SNX18_HUMAN (1-491): 6.4e-119: 367: 45.84
+	Hs
		1105806 ADA15_HUMAN (30-804): 3.62e-138: 432: 31.10		SNX30_HUMAN (143-573): 5.64e-68: 228: 18.79
+	Hs
		161062 ADA10_HUMAN (51-517): 7.84e-24: 109: 25.14		SNX33_HUMAN (1-574): 1.53e-158: 467: 100.00
+	Hs
		1008439 ADA17_HUMAN (140-517): 2.97e-19: 95.1: 24.61		SNX33_HUMAN (1-574): 1.53e-158: 467: 100.00
+	Hs
		161110 ADA10_HUMAN (51-517): 7.84e-24: 109: 25.14		SNX9_HUMAN (1-571): 1.4e-140: 421: 34.18
+	Hs
		1008464 ADA17_HUMAN (140-517): 2.97e-19: 95.1: 24.61		SNX9_HUMAN (1-571): 1.4e-140: 421: 34.18
+	Hs
		161075 ADA10_HUMAN (51-517): 7.84e-24: 109: 25.14		SNX18_HUMAN (1-491): 6.4e-119: 367: 45.84
+	Hs
		1008447 ADA17_HUMAN (140-517): 2.97e-19: 95.1: 24.61		SNX18_HUMAN (1-491): 6.4e-119: 367: 45.84
+	Hs
		160954 ADA10_HUMAN (51-517): 7.84e-24: 109: 25.14		GAS7_HUMAN (2-478): 1.69e-54: 193: 13.21