HitPredict

Interactor 1: CUL2 (Q13617)
Cullin-2 (CUL-2)
Gene: CUL2

Interactor 2: K1C27 (Q7Z3Y8)
Keratin, type I cytoskeletal 27 (Cytokeratin-27) (CK-27) (Keratin-25C) (K25C) (Keratin-27) (K27) (Type I inner root sheath-specific keratin-K25irs3)
Gene: KRT27

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 745 Hs			1 459
+	Hs
		385098 CUL2_HUMAN (1-745): 0: 839: 100.00		K1C14_HUMAN (61-446): 7.8e-148: 431: 54.26
+	Hs
		1112860 CUL2_HUMAN (1-745): 0: 839: 100.00		K1C24_HUMAN (79-428): 2.28e-128: 383: 61.93
+	Hs
		566146 CUL2_HUMAN (1-745): 0: 839: 100.00		K1C10_HUMAN (53-393): 2.08e-124: 375: 65.98
+	Hs
		385097 CUL1_HUMAN (6-745): 0: 770: 36.24		K1C14_HUMAN (61-446): 7.8e-148: 431: 54.26
+	Hs
		476308 CUL2_HUMAN (1-745): 0: 839: 100.00		K1C16_HUMAN (80-406): 1.64e-119: 359: 60.55
+	Hs
		566262 CUL2_HUMAN (1-745): 0: 839: 100.00		K1C13_HUMAN (72-397): 2.21e-118: 355: 59.51
+	Hs
		385268 CUL2_HUMAN (1-745): 0: 839: 100.00		K2C6A_HUMAN (55-419): 1e-114: 350: 20.70
+	Hs
		1112518 CUL1_HUMAN (6-745): 0: 770: 36.24		K1C24_HUMAN (79-428): 2.28e-128: 383: 61.93
+	Hs
		566145 CUL1_HUMAN (6-745): 0: 770: 36.24		K1C10_HUMAN (53-393): 2.08e-124: 375: 65.98
+	Hs
		476307 CUL1_HUMAN (6-745): 0: 770: 36.24		K1C16_HUMAN (80-406): 1.64e-119: 359: 60.55
+	Hs
		566261 CUL1_HUMAN (6-745): 0: 770: 36.24		K1C13_HUMAN (72-397): 2.21e-118: 355: 59.51
+	Hs
		385267 CUL1_HUMAN (6-745): 0: 770: 36.24		K2C6A_HUMAN (55-419): 1e-114: 350: 20.70
+	Hs
		341766 CUL2_HUMAN (1-745): 0: 839: 100.00		K2C75_HUMAN (2-411): 1.81e-87: 279: 23.71
+	Hs
		1112863 CUL2_HUMAN (1-745): 0: 839: 100.00		K2C71_HUMAN (3-405): 1.06e-79: 258: 22.22
+	Hs
		566370 CUL2_HUMAN (1-745): 0: 839: 100.00		K2C5_HUMAN (55-402): 1.15e-72: 241: 22.54
+	Hs
		876465 CUL2_HUMAN (1-745): 0: 839: 100.00		K2C6C_HUMAN (55-415): 2.47e-72: 240: 20.65
+	Hs
		341765 CUL1_HUMAN (6-745): 0: 770: 36.24		K2C75_HUMAN (2-411): 1.81e-87: 279: 23.71
+	Hs
		566369 CUL1_HUMAN (6-745): 0: 770: 36.24		K2C5_HUMAN (55-402): 1.15e-72: 241: 22.54
+	Hs
		407285 CUL1_HUMAN (6-745): 0: 770: 36.24		K2C6B_HUMAN (55-418): 1.5e-72: 240: 19.95
+	Hs
		876464 CUL1_HUMAN (6-745): 0: 770: 36.24		K2C6C_HUMAN (55-415): 2.47e-72: 240: 20.65