HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: TULP4 (Q9NRJ4)
Tubby-related protein 4 (Tubby superfamily protein) (Tubby-like protein 4)
Gene: TULP4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	37788672
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Cullin~SOCS_box
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016567 - protein ubiquitination
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 768 Hs			1 1543
+	Hs
		1371877 CUL5_HUMAN (25-768): 0: 597: 23.77		TULP4_HUMAN (1-1543): 0: 1885: 100.00
+	Hs
		279360 CUL3_HUMAN (1-768): 0: 943: 100.00		TULP3_HUMAN (1296-1542): 3.12e-90: 302: 20.39
+	Hs
		1114524 CUL3_HUMAN (1-768): 0: 943: 100.00		WDR35_HUMAN (19-405): 4.39e-81: 294: 26.77
+	Hs
		1114438 CUL3_HUMAN (1-768): 0: 943: 100.00		NLE1_HUMAN (12-152): 2.27e-32: 135: 13.01
+	Hs
		1113779 CUL3_HUMAN (1-768): 0: 943: 100.00		POC1B_HUMAN (159-367): 5.98e-26: 115: 13.31
+	Hs
		964927 CUL3_HUMAN (1-768): 0: 943: 100.00		WDR5_HUMAN (248-467): 1.58e-21: 99.8: 10.30
+	Hs
		261407 CUL4B_HUMAN (5-768): 0: 796: 36.77		TBL1X_HUMAN (7-318): 6.06e-51: 192: 13.04
+	Hs
		1115406 CUL4B_HUMAN (5-768): 0: 796: 36.77		TBL1R_HUMAN (4-304): 4.19e-50: 188: 11.52
+	Hs
		1114950 CUL4A_HUMAN (10-768): 0: 801: 38.32		POC1B_HUMAN (159-367): 5.98e-26: 115: 13.31
+	Hs
		1115313 CUL4B_HUMAN (5-768): 0: 796: 36.77		POC1B_HUMAN (159-367): 5.98e-26: 115: 13.31
+	Hs
		1114921 CUL4A_HUMAN (10-768): 0: 801: 38.32		WDR5B_HUMAN (249-467): 1.1e-22: 102: 9.48
+	Hs
		214570 CUL4A_HUMAN (10-768): 0: 801: 38.32		WDR62_HUMAN (21-360): 3.96e-20: 99.8: 10.09
+	Hs
		964928 CUL4A_HUMAN (10-768): 0: 801: 38.32		WDR5_HUMAN (248-467): 1.58e-21: 99.8: 10.30
+	Hs
		1115283 CUL4B_HUMAN (5-768): 0: 796: 36.77		WDR5B_HUMAN (249-467): 1.1e-22: 102: 9.48
+	Hs
		214571 CUL4B_HUMAN (5-768): 0: 796: 36.77		WDR62_HUMAN (21-360): 3.96e-20: 99.8: 10.09
+	Hs
		964929 CUL4B_HUMAN (5-768): 0: 796: 36.77		WDR5_HUMAN (248-467): 1.58e-21: 99.8: 10.30
+	Hs
		845297 CUL4A_HUMAN (10-768): 0: 801: 38.32		LIS1_HUMAN (250-440): 5.67e-19: 93.3: 10.14
+	Hs
		845298 CUL4B_HUMAN (5-768): 0: 796: 36.77		LIS1_HUMAN (250-440): 5.67e-19: 93.3: 10.14
+	Hs
		964926 CUL1_HUMAN (18-768): 0: 709: 30.57		WDR5_HUMAN (248-467): 1.58e-21: 99.8: 10.30