HitPredict

Interactor 1: SHAN3 (Q4ACU6)
SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) (SPANK-2)
Gene: Shank3

Interactor 2: SPTB2 (Q62261)
Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Embryonic liver fodrin) (Fodrin beta chain)
Gene: Sptbn1

Species: Mus musculus

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.650

Property	Details
Experiments	27507650, 28671696, 28469556
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0014069 - postsynaptic density GO:0044877 - protein-containing complex binding GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1730 Mm			1 2363
+	Mm
		1115949 SHAN3_MOUSE (1-1730): 0: 626: 100.00		Q68FG2_MOUSE (2-2363): 0: 629: 61.10
+	Hs
		862027 DAPK1_HUMAN (17-450): 1.03e-87: 318: 15.97		SPTB2_HUMAN (1-2363): 0: 749: 98.27
+	Mm
		103603 ANK3_MOUSE (41-592): 7.79e-85: 311: 15.58		SPTB2_MOUSE (1-2363): 0: 750: 100.00
+	Mm
		885079 SHAN3_MOUSE (1-1730): 0: 626: 100.00		ACTN4_MOUSE (53-525): 4.74e-121: 409: 47.58
+	Mm
		103598 ANK3_MOUSE (41-592): 7.79e-85: 311: 15.58		Q3UGX2_MOUSE (4-2310): 0: 673: 58.60
+	Mm
		1115975 SHAN3_MOUSE (1-1730): 0: 626: 100.00		ACTN1_MOUSE (40-763): 7.59e-91: 319: 35.48
+	Hs
		521605 SHAN3_HUMAN (1-1730): 0: 601: 95.21		ACTN1_HUMAN (40-763): 1.33e-92: 325: 35.35
+	Mm
		561160 SHAN3_MOUSE (1-1730): 0: 626: 100.00		SPTN1_MOUSE (604-2355): 1.07e-63: 244: 20.52
+	Mm
		82760 SHAN3_MOUSE (1-1730): 0: 626: 100.00		B9EKJ1_MOUSE (604-2355): 3.04e-63: 242: 20.41
+	Rn
		555260 SHAN3_RAT (1-1730): 0: 618: 98.39		SPTN1_RAT (604-2355): 8.02e-64: 244: 20.52
+	Hs
		1045505 SHAN3_HUMAN (1-1730): 0: 601: 95.21		SPTN1_HUMAN (604-2355): 1.8e-64: 246: 20.35
+	Mm
		1116155 SHAN3_MOUSE (1-1730): 0: 626: 100.00		MACF1_MOUSE (454-2218): 7.55e-47: 189: 12.25
+	Mm
		93255 SHAN3_MOUSE (1-1730): 0: 626: 100.00		E9PX29_MOUSE (1034-2347): 9.61e-23: 109: 15.10
+	Hs
		211541 DAPK1_HUMAN (17-450): 1.03e-87: 318: 15.97		ACTN4_HUMAN (53-525): 3.62e-121: 409: 47.58
+	Hs
		521508 DAPK1_HUMAN (17-450): 1.03e-87: 318: 15.97		ACTN1_HUMAN (40-763): 1.33e-92: 325: 35.35
+	Hs
		862037 DAPK1_HUMAN (17-450): 1.03e-87: 318: 15.97		SPTN1_HUMAN (604-2355): 1.8e-64: 246: 20.35
+	Mm
		82740 ANK3_MOUSE (41-592): 7.79e-85: 311: 15.58		B9EKJ1_MOUSE (604-2355): 3.04e-63: 242: 20.41
+	Hs
		164586 DAPK1_HUMAN (17-450): 1.03e-87: 318: 15.97		SPTN2_HUMAN (1028-2358): 8.4e-34: 146: 15.55
+	Hs
		164611 ANK3_HUMAN (12-592): 2.9e-68: 258: 15.01		SPTN2_HUMAN (1028-2358): 8.4e-34: 146: 15.55
+	Rn
		251022 ANK3_RAT (12-592): 2.73e-71: 268: 14.49		PLEC_RAT (235-878): 1.2e-09: 66.3: 9.41