HitPredict - High confidence protein-protein interactions

Interactor 1: SHAN3 (Q4ACU6)
SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) (SPANK-2)
Gene: Shank3

Interactor 2: SHAN2 (Q80Z38)
SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin-binding protein 1) (CortBP1)
Gene: Shank2

Species: Mus musculus

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.881

Property	Details
Experiments	27507650, 28671696, 36417873, 28469556
Identification Methods	affinity chromatography technology, proximity labelling technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PDZ_6~PDZ_6, SAM_1~SAM_1, SH3_2~SH3_2
Common GO terms	GO:0005886 - plasma membrane GO:0007416 - synapse assembly GO:0007612 - learning GO:0007613 - memory GO:0008306 - associative learning and 17 others more... GO:0014069 - postsynaptic density GO:0017124 - SH3 domain binding GO:0030160 - synaptic receptor adaptor activity GO:0035176 - social behavior GO:0035255 - ionotropic glutamate receptor binding GO:0035640 - exploration behavior GO:0043005 - neuron projection GO:0043197 - dendritic spine GO:0045211 - postsynaptic membrane GO:0051968 - positive regulation of synaptic transmission, glutamatergic GO:0060170 - ciliary membrane GO:0060291 - long-term synaptic potentiation GO:0060292 - long-term synaptic depression GO:0071625 - vocalization behavior GO:0098919 - structural constituent of postsynaptic density GO:0098978 - glutamatergic synapse GO:0099175 - regulation of postsynapse organization
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1	1730
Mm

1	1476

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Last updated: 15 Jul 2024