Protein: RN146
E3 ubiquitin-protein ligase RNF146 (EC 2.3.2.27) (Dactylidin) (Iduna) (RING finger protein 146) (RING-type E3 ubiquitin transferase RNF146)

Gene: RN146, RNF146
Organism: Homo sapiens
Interactions: 102
UniProt ID: Q9NTX7

Gene Ontology (top 5):
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

895926

UB2D3
Ubiquitin-conjugating enzyme E2 D3

2

2

Small-scale

0.806

High

1345809

RN146
E3 ubiquitin-protein ligase RNF146

3

0

Small-scale

0.792

High

455921

PARP1
Poly [ADP-ribose] polymerase 1

5

4

Small-scale

0.726

High

1345813

PARP2
Poly [ADP-ribose] polymerase 2

5

3

Small-scale

0.712

High

310097

TNKS1
Poly [ADP-ribose] polymerase tankyrase-1

4

1

Small-scale

0.711

High

849458

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

2

Small-scale

0.710

High

891442

UB2G2
Ubiquitin-conjugating enzyme E2 G2

1

3

High-throughput

0.698

High

909196

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.698

High

836788

DNLI3
DNA ligase 3

4

0

Small-scale

0.661

High

996922

SSRP1
FACT complex subunit SSRP1

4

0

Small-scale

0.661

High

1203237

CHD1L
Chromodomain-helicase-DNA-binding protein 1-like

4

0

Small-scale

0.661

High

1345818

SP16H
FACT complex subunit SPT16

4

0

Small-scale

0.661

High

919875

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

2

Small-scale

0.647

High

1020954

TRAF2
TNF receptor-associated factor 2

3

0

High-throughput

0.646

High

781597

CETN2
Centrin-2

3

0

High-throughput

0.638

High

967087

XPC
DNA repair protein complementing XP-C cells

3

0

High-throughput

0.638

High

1055171

HLTF
Helicase-like transcription factor

3

0

Small-scale

0.606

High

1345817

AXIN2
Axin-2

2

1

Small-scale

0.601

High

1329535

TNKS2
Poly [ADP-ribose] polymerase tankyrase-2

2

1

Small-scale

0.594

High

579745

XRCC1
DNA repair protein XRCC1

2

0

Small-scale

0.592

High

163350

XPO1
Exportin-1

2

1

Small-scale

0.584

High

1312578

NDUF3
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3

2

0

High-throughput

0.580

High

524034

XRCC6
X-ray repair cross-complementing protein 6

1

1

Small-scale

0.561

High

1345812

GCP4
Gamma-tubulin complex component 4

1

0

High-throughput

0.549

High

924185

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

0

Small-scale

0.546

High

1192241

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

0

Small-scale

0.546

High

715006

PROF2
Profilin-2

1

0

High-throughput

0.518

High

1119072

AMOT
Angiomotin

1

2

Small-scale

0.515

High

1222272

AMOL1
Angiomotin-like protein 1

1

2

Small-scale

0.515

High

1246443

INADL
InaD-like protein

1

5

Small-scale

0.515

High

1345815

AMOL2
Angiomotin-like protein 2

1

2

Small-scale

0.515

High

1330292

BORG4
Cdc42 effector protein 4

1

0

High-throughput

0.513

High

835258

NDUV1
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

1

0

High-throughput

0.493

High

170726

AXIN1
Axin-1

1

1

Small-scale

0.479

High

225248

3BP5
SH3 domain-binding protein 5

1

1

Small-scale

0.479

High

280081

MPDZ
Multiple PDZ domain protein

1

5

Small-scale

0.479

High

312402

IPO7
Importin-7

1

1

Small-scale

0.479

High

525081

XRCC5
X-ray repair cross-complementing protein 5

1

1

Small-scale

0.479

High

719634

MERL
Merlin

1

1

Small-scale

0.479

High

751854

GRP75
Stress-70 protein, mitochondrial

1

1

Small-scale

0.479

High

823500

PAXI
Paxillin

1

1

Small-scale

0.479

High

876515

AFAD
Afadin

1

4

Small-scale

0.479

High

1044717

FHL3
Four and a half LIM domains protein 3

1

1

Small-scale

0.479

High

1050074

SCRIB
Protein scribble homolog

1

2

Small-scale

0.479

High

1071581

L2GL1
Lethal(2) giant larvae protein homolog 1

1

1

Small-scale

0.479

High

1158584

L2GL2
LLGL scribble cell polarity complex component 2

1

1

Small-scale

0.479

High

1185296

3BP5L
SH3 domain-binding protein 5-like

1

1

Small-scale

0.479

High

1294457

AJUBA
LIM domain-containing protein ajuba

1

1

Small-scale

0.479

High

1316960

PAR6G
Partitioning defective 6 homolog gamma

1

2

Small-scale

0.479

High

1326242

SENP6
Sentrin-specific protease 6

1

2

Small-scale

0.479

High

1335816

SENP2
Sentrin-specific protease 2

1

2

Small-scale

0.479

High

1342592

PAR6A
Partitioning defective 6 homolog alpha

1

3

Small-scale

0.479

High

1345811

SENP1
Sentrin-specific protease 1

1

2

Small-scale

0.479

High

1345816

FRM4B
FERM domain-containing protein 4B

1

2

Small-scale

0.479

High

127381

IPO5
Importin-5

1

0

Small-scale

0.458

High

208795

SNAI2
Zinc finger protein SNAI2

1

0

Small-scale

0.458

High

428462

TBB5
Tubulin beta chain

1

0

Small-scale

0.458

High

502600

BIP
Endoplasmic reticulum chaperone BiP

1

0

Small-scale

0.458

High

559969

H12
Histone H1.2

1

0

Small-scale

0.458

High

582522

NUCL
Nucleolin

1

0

Small-scale

0.458

High

583374

HXK1
Hexokinase-1

1

0

Small-scale

0.458

High

626265

APC
Adenomatous polyposis coli protein

1

0

Small-scale

0.458

High

637077

ATPA
ATP synthase subunit alpha, mitochondrial

1

0

Small-scale

0.458

High

890860

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

0

Small-scale

0.458

High

962399

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

0

Small-scale

0.458

High

983929

KPCZ
Protein kinase C zeta type

1

0

Small-scale

0.458

High

1042638

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1079167

STK11
Serine/threonine-protein kinase STK11

1

0

Small-scale

0.458

High

1216273

H2A2B
Histone H2A type 2-B

1

0

High-throughput

0.458

High

1291928

OTUD5
OTU domain-containing protein 5

1

0

Small-scale

0.458

High

1297862

NSE2
E3 SUMO-protein ligase NSE2

1

0

Small-scale

0.458

High

1329396

GO45
Golgin-45

1

0

Small-scale

0.458

High

1342798

BRD7
Bromodomain-containing protein 7

1

0

High-throughput

0.458

High

1345819

PIAS3
E3 SUMO-protein ligase PIAS3

1

0

Small-scale

0.458

High

598343

FLNA
Filamin-A

1

1

Small-scale

0.445

High

764705

CUX1
Homeobox protein cut-like 1

1

1

Small-scale

0.445

High

1020227

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

1

Small-scale

0.445

High

1021572

DLG1
Disks large homolog 1

1

2

Small-scale

0.445

High

1132896

MPP7
MAGUK p55 subfamily member 7

1

1

Small-scale

0.445

High

1136438

MAGI3
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3

1

5

Small-scale

0.445

High

1345810

SMAL1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1

1

1

Small-scale

0.445

High

1190108

MAVS
Mitochondrial antiviral-signaling protein

1

1

Small-scale

0.437

High

195561

DHX15
ATP-dependent RNA helicase DHX15

1

0

Small-scale

0.426

High

553837

RFA2
Replication protein A 32 kDa subunit

1

0

Small-scale

0.426

High

652374

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

Small-scale

0.426

High

722300

RFC1
Replication factor C subunit 1

1

0

Small-scale

0.426

High

783121

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

0

Small-scale

0.426

High

790027

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

Small-scale

0.426

High

809451

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

0

Small-scale

0.426

High

944458

PRKDC
DNA-dependent protein kinase catalytic subunit

1

0

Small-scale

0.426

High

963438

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

0

Small-scale

0.426

High

1050626

WRN
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN

1

0

Small-scale

0.426

High

1082417

DDB1
DNA damage-binding protein 1

1

0

Small-scale

0.426

High

1123443

H90B4
Putative heat shock protein HSP 90-beta 4

1

0

High-throughput

0.426

High

1131607

ZMYM1
Zinc finger MYM-type protein 1

1

0

Small-scale

0.426

High

1272041

RAD50
DNA repair protein RAD50

1

0

Small-scale

0.426

High

1345814

RUVB2
RuvB-like 2

1

0

Small-scale

0.426

High

1236093

KASH5
Protein KASH5

4

0

High-throughput

0.369

High

281913

WFS1
Wolframin

1

0

High-throughput

0.268

Low

940677

3BP2
SH3 domain-binding protein 2

1

0

Small-scale

0.249

Low

1332420

WDCP
WD repeat and coiled-coil-containing protein

1

0

Small-scale

0.232

Low


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Last updated: 15 Jul 2024