HitPredict

Interactor 1: KGP1 (Q13976)
cGMP-dependent protein kinase 1 (cGK 1) (cGK1) (EC 2.7.11.12) (cGMP-dependent protein kinase I) (cGKI)
Gene: PRKG1

Interactor 2: KGP1 (Q13976)
cGMP-dependent protein kinase 1 (cGK 1) (cGK1) (EC 2.7.11.12) (cGMP-dependent protein kinase I) (cGKI)
Gene: PRKG1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.72 1.00 0.854

The method score is based on:

Property Details
Experiments 36949045, 27066748, 20826808
Identification Methods two hybrid, x-ray crystallography, x ray scattering
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains cNMP_binding~cNMP_binding, Pkinase~cNMP_binding, PKcGMP_CC~PKcGMP_CC, Pkinase~Pkinase
Common GO terms GO:0001669 - acrosomal vesicle
GO:0001764 - neuron migration
GO:0004672 - protein kinase activity
GO:0004692 - cGMP-dependent protein kinase activity
GO:0005246 - calcium channel regulator activity
and 30 others

more...
Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 671
Hs

1 671
+ Bt
+ Ce
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Zm
+ Hs
+ Hs
+ Hs
+ Hs
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+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 11Aug2025