HitPredict

Interactor 1: KLH12 (Q53G59)
Kelch-like protein 12 (CUL3-interacting protein 1) (DKIR homolog) (hDKIR)
Gene: KLHL12

Interactor 2: CSN6 (Q7L5N1)
COP9 signalosome complex subunit 6 (SGN6) (Signalosome subunit 6) (JAB1-containing signalosome subunit 6) (MOV34 homolog) (Vpr-interacting protein) (hVIP)
Gene: COPS6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	21145461, 30190310
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 568 Hs			1 327
+	Hs
		1185018 KLH20_HUMAN (2-566): 1.23e-174: 509: 43.94		CSN6_HUMAN (1-327): 1.8e-141: 404: 100.00
+	Hs
		299521 KLH18_HUMAN (5-565): 1.58e-159: 469: 39.79		CSN6_HUMAN (1-327): 1.8e-141: 404: 100.00
+	Hs
		1184998 KLHL8_HUMAN (5-565): 5.61e-156: 461: 37.41		CSN6_HUMAN (1-327): 1.8e-141: 404: 100.00
+	Hs
		1185001 KLH13_HUMAN (380-568): 2.64e-43: 165: 28.06		CSN6_HUMAN (1-327): 1.8e-141: 404: 100.00
+	Hs
		1184999 KLHL9_HUMAN (380-568): 3.91e-43: 164: 27.55		CSN6_HUMAN (1-327): 1.8e-141: 404: 100.00
+	Hs
		1153783 KLH10_HUMAN (428-568): 1.65e-33: 136: 33.80		CSN6_HUMAN (1-327): 1.8e-141: 404: 100.00
+	Hs
		1121474 KLH26_HUMAN (365-568): 5.54e-30: 126: 23.26		CSN6_HUMAN (1-327): 1.8e-141: 404: 100.00
+	Hs
		1164611 KLH24_HUMAN (394-568): 1.15e-28: 122: 29.67		CSN6_HUMAN (1-327): 1.8e-141: 404: 100.00