Protein: NCOA3
Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1)

Gene: NCOA3
Organism: Homo sapiens
Interactions: 170
UniProt ID: Q9Y6Q9

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000993 - RNA polymerase II complex binding
GO:0003713 - transcription coactivator activity
GO:0004402 - histone acetyltransferase activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

370839

ESR1
Estrogen receptor

29

20

Small-scale

0.992

High

1270854

CBP
CREB-binding protein

12

20

Small-scale

0.977

High

999268

EP300
Histone acetyltransferase p300

9

20

Small-scale

0.974

High

488043

RARA
Retinoic acid receptor alpha

8

20

Small-scale

0.964

High

1270064

ESR2
Estrogen receptor beta

8

20

Small-scale

0.964

High

487882

ANDR
Androgen receptor

8

20

Small-scale

0.960

High

740635

PPARG
Peroxisome proliferator-activated receptor gamma

8

20

Small-scale

0.950

High

377843

GCR
Glucocorticoid receptor

6

20

Small-scale

0.924

High

510000

VDR
Vitamin D3 receptor

5

20

Small-scale

0.914

High

587212

RXRA
Retinoic acid receptor RXR-alpha

4

20

Small-scale

0.888

High

510047

ERR1
Steroid hormone receptor ERR1

4

20

Small-scale

0.882

High

500511

THB
Thyroid hormone receptor beta

3

20

Small-scale

0.861

High

414535

PRGR
Progesterone receptor

3

20

Small-scale

0.834

High

975487

PPARD
Peroxisome proliferator-activated receptor delta

2

20

Small-scale

0.778

High

348397

MYC
Myc proto-oncogene protein

2

9

Small-scale

0.754

High

1075403

NCOA2
Nuclear receptor coactivator 2

2

20

Small-scale

0.754

High

1078553

NCOA1
Nuclear receptor coactivator 1

2

19

Small-scale

0.743

High

1204121

CARM1
Histone-arginine methyltransferase CARM1

6

8

Small-scale

0.738

High

214434

SPOP
Speckle-type POZ protein

5

2

Small-scale

0.725

High

167643

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

4

7

Small-scale

0.704

High

1335642

ARNT2
Aryl hydrocarbon receptor nuclear translocator 2

1

20

High-throughput

0.698

High

320237

ERR2
Steroid hormone receptor ERR2

1

20

Small-scale

0.647

High

611537

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

20

Small-scale

0.647

High

992458

PPARA
Peroxisome proliferator-activated receptor alpha

1

20

Small-scale

0.647

High

1061339

NR1I3
Nuclear receptor subfamily 1 group I member 3

1

20

Small-scale

0.647

High

1306198

NPAS2
Neuronal PAS domain-containing protein 2

1

19

Small-scale

0.647

High

158577

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

2

6

Small-scale

0.646

High

899096

PSME3
Proteasome activator complex subunit 3

2

1

Small-scale

0.641

High

1378218

NEMO
NF-kappa-B essential modulator

2

18

Small-scale

0.634

High

1082666

MK14
Mitogen-activated protein kinase 14

2

6

Small-scale

0.633

High

963715

E2F1
Transcription factor E2F1

2

3

Small-scale

0.629

High

130340

NR5A2
Nuclear receptor subfamily 5 group A member 2

1

20

Small-scale

0.621

High

265886

NR1I2
Nuclear receptor subfamily 1 group I member 2

1

20

Small-scale

0.621

High

490120

COT1
COUP transcription factor 1

1

20

Small-scale

0.621

High

530818

RARG
Retinoic acid receptor gamma

1

20

High-throughput

0.621

High

874407

NR1H2
Oxysterols receptor LXR-beta

1

20

High-throughput

0.621

High

1025276

NR1H3
Oxysterols receptor LXR-alpha

1

20

High-throughput

0.621

High

1074328

NR0B2
Nuclear receptor subfamily 0 group B member 2

1

20

Small-scale

0.621

High

500381

RARB
Retinoic acid receptor beta

1

20

Small-scale

0.618

High

500455

THA
Thyroid hormone receptor alpha

1

20

Small-scale

0.618

High

782708

HNF4A
Hepatocyte nuclear factor 4-alpha

1

20

High-throughput

0.618

High

786509

STAT6
Signal transducer and activator of transcription 6

1

8

Small-scale

0.618

High

846431

RORG
Nuclear receptor ROR-gamma

1

20

Small-scale

0.618

High

750002

BRCA1
Breast cancer type 1 susceptibility protein

2

12

Small-scale

0.613

High

659101

MK01
Mitogen-activated protein kinase 1

2

4

Small-scale

0.602

High

918234

H4
Histone H4

2

7

Small-scale

0.602

High

1086370

H31T
Histone H3.1t

2

6

Small-scale

0.602

High

799166

NKX21
Homeobox protein Nkx-2.1

2

20

Small-scale

0.594

High

1271525

KAT2B
Histone acetyltransferase KAT2B

2

12

Small-scale

0.594

High

830517

KC1E
Casein kinase I isoform epsilon

1

8

Small-scale

0.586

High

656148

PSB9
Proteasome subunit beta type-9

1

3

Small-scale

0.586

High

1038100

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

2

Small-scale

0.586

High

585104

RO52
E3 ubiquitin-protein ligase TRIM21

2

5

Small-scale

0.584

High

622556

CCND1
G1/S-specific cyclin-D1

2

5

Small-scale

0.584

High

818674

SOX2
Transcription factor SOX-2

2

20

Small-scale

0.584

High

978955

TF65
Transcription factor p65

2

9

Small-scale

0.584

High

1078711

SMAD2
Mothers against decapentaplegic homolog 2

2

10

Small-scale

0.584

High

1080534

EZH2
Histone-lysine N-methyltransferase EZH2

2

15

Small-scale

0.584

High

261619

NCOR1
Nuclear receptor corepressor 1

1

15

Small-scale

0.561

High

337613

ABL1
Tyrosine-protein kinase ABL1

1

6

Small-scale

0.561

High

345594

FOS
Protein c-Fos

1

13

Small-scale

0.561

High

595966

HNF1A
Hepatocyte nuclear factor 1-alpha

1

13

Small-scale

0.561

High

840443

ETV1
ETS translocation variant 1

1

20

Small-scale

0.561

High

983955

KPCZ
Protein kinase C zeta type

1

6

Small-scale

0.561

High

1019196

TP53B
TP53-binding protein 1

1

2

Small-scale

0.561

High

1224729

MYCD
Myocardin

1

7

Small-scale

0.561

High

1378167

NCOR2
Nuclear receptor corepressor 2

1

9

Small-scale

0.561

High

525116

XRCC5
X-ray repair cross-complementing protein 5

1

5

High-throughput

0.536

High

535970

MIF
Macrophage migration inhibitory factor

1

2

High-throughput

0.536

High

845912

RAB28
Ras-related protein Rab-28

1

2

High-throughput

0.536

High

1099416

T132A
Transmembrane protein 132A

1

1

High-throughput

0.536

High

1144826

KANK2
KN motif and ankyrin repeat domain-containing protein 2

1

7

Small-scale

0.536

High

1347444

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

2

High-throughput

0.536

High

1162762

ATAD2
ATPase family AAA domain-containing protein 2

1

2

Small-scale

0.534

High

1164809

ANR11
Ankyrin repeat domain-containing protein 11

1

5

Small-scale

0.527

High

1303034

MMS19
MMS19 nucleotide excision repair protein homolog

1

1

Small-scale

0.527

High

888472

EIF3E
Eukaryotic translation initiation factor 3 subunit E

1

1

Small-scale

0.515

High

890919

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

2

Small-scale

0.515

High

1048305

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

3

High-throughput

0.515

High

1287457

OPTN
Optineurin

1

15

High-throughput

0.515

High

363962

ALBU
Albumin

1

0

High-throughput

0.513

High

387825

P53
Cellular tumor antigen p53

1

9

Small-scale

0.501

High

647429

1433T
14-3-3 protein theta

1

3

Small-scale

0.501

High

800854

MK08
Mitogen-activated protein kinase 8

1

6

Small-scale

0.501

High

836134

GSK3B
Glycogen synthase kinase-3 beta

1

3

Small-scale

0.501

High

1282562

MRTFA
Myocardin-related transcription factor A

1

4

Small-scale

0.501

High

1307086

ANM1
Protein arginine N-methyltransferase 1

1

8

Small-scale

0.501

High

1356886

MRTFB
Myocardin-related transcription factor B

1

9

Small-scale

0.501

High

1014239

MN1
Transcriptional activator MN1

1

0

Small-scale

0.480

High

135182

NFIB
Nuclear factor 1 B-type

1

5

High-throughput

0.479

High

163539

XPO1
Exportin-1

1

8

High-throughput

0.479

High

171101

TBXT
T-box transcription factor T

1

7

High-throughput

0.479

High

197864

CRX
Cone-rod homeobox protein

1

18

High-throughput

0.479

High

198079

PHF1
PHD finger protein 1

1

2

Small-scale

0.479

High

204247

KLF4
Krueppel-like factor 4

1

14

High-throughput

0.479

High

212008

TLX3
T-cell leukemia homeobox protein 3

1

14

High-throughput

0.479

High

225814

SOX15
Transcription factor SOX-15

1

20

High-throughput

0.479

High

245146

BRD4
Bromodomain-containing protein 4

1

7

High-throughput

0.479

High

278197

PIAS1
E3 SUMO-protein ligase PIAS1

1

7

Small-scale

0.479

High

317049

KLF8
Krueppel-like factor 8

1

14

High-throughput

0.479

High

318764

EYA4
Eyes absent homolog 4

1

6

High-throughput

0.479

High

331912

NSD2
Histone-lysine N-methyltransferase NSD2

1

15

Small-scale

0.479

High

360673

SPTA1
Spectrin alpha chain, erythrocytic 1

1

4

Small-scale

0.479

High

427708

ANXA2
Annexin A2

1

1

Small-scale

0.479

High

443277

NFIC
Nuclear factor 1 C-type

1

6

High-throughput

0.479

High

505321

EGR2
E3 SUMO-protein ligase EGR2

1

4

High-throughput

0.479

High

507535

ERG
Transcriptional regulator ERG

1

19

High-throughput

0.479

High

518941

TPR
Nucleoprotein TPR

1

9

Small-scale

0.479

High

542091

ETS1
Protein C-ets-1

1

19

Small-scale

0.479

High

542769

ETS2
Protein C-ets-2

1

20

Small-scale

0.479

High

587764

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

10

Small-scale

0.479

High

610196

RFX1
MHC class II regulatory factor RFX1

1

15

Small-scale

0.479

High

620231

PAX7
Paired box protein Pax-7

1

19

High-throughput

0.479

High

620450

GATA2
Endothelial transcription factor GATA-2

1

5

High-throughput

0.479

High

620600

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

5

High-throughput

0.479

High

638057

PSA3
Proteasome subunit alpha type-3

1

2

Small-scale

0.479

High

641617

PAX6
Paired box protein Pax-6

1

15

High-throughput

0.479

High

679202

TLX1
T-cell leukemia homeobox protein 1

1

15

High-throughput

0.479

High

725093

MYH9
Myosin-9

1

8

Small-scale

0.479

High

727622

HNF1B
Hepatocyte nuclear factor 1-beta

1

19

High-throughput

0.479

High

727952

SOX6
Transcription factor SOX-6

1

20

High-throughput

0.479

High

794578

ETV4
ETS translocation variant 4

1

20

High-throughput

0.479

High

818854

SOX9
Transcription factor SOX-9

1

20

High-throughput

0.479

High

830065

HXA1
Homeobox protein Hox-A1

1

9

Small-scale

0.479

High

831861

CEBPA
CCAAT/enhancer-binding protein alpha

1

14

High-throughput

0.479

High

877654

FOXG1
Forkhead box protein G1

1

12

Small-scale

0.479

High

877985

FOXA1
Hepatocyte nuclear factor 3-alpha

1

11

High-throughput

0.479

High

878484

PAX9
Paired box protein Pax-9

1

15

High-throughput

0.479

High

881838

SOX10
Transcription factor SOX-10

1

20

High-throughput

0.479

High

882175

GSC
Homeobox protein goosecoid

1

11

High-throughput

0.479

High

907206

PRS8
26S proteasome regulatory subunit 8

1

8

Small-scale

0.479

High

933080

ACTS
Actin, alpha skeletal muscle

1

1

Small-scale

0.479

High

950348

SMAD3
Mothers against decapentaplegic homolog 3

1

10

Small-scale

0.479

High

967540

EWS
RNA-binding protein EWS

1

5

High-throughput

0.479

High

973898

PAX2
Paired box protein Pax-2

1

15

High-throughput

0.479

High

980925

TLE3
Transducin-like enhancer protein 3

1

14

High-throughput

0.479

High

983285

UBE3A
Ubiquitin-protein ligase E3A

1

7

Small-scale

0.479

High

985690

CTSL2
CTD small phosphatase-like protein 2

1

1

Small-scale

0.479

High

988822

PAX8
Paired box protein Pax-8

1

15

High-throughput

0.479

High

1018288

NFIA
Nuclear factor 1 A-type

1

5

High-throughput

0.479

High

1021274

FOXI1
Forkhead box protein I1

1

9

High-throughput

0.479

High

1021747

NFAC3
Nuclear factor of activated T-cells, cytoplasmic 3

1

11

Small-scale

0.479

High

1042962

CUL3
Cullin-3

1

9

Small-scale

0.479

High

1046781

KLF5
Krueppel-like factor 5

1

14

High-throughput

0.479

High

1064300

TNIP1
TNFAIP3-interacting protein 1

1

7

High-throughput

0.479

High

1071086

IRF4
Interferon regulatory factor 4

1

3

High-throughput

0.479

High

1085199

TBR1
T-box brain protein 1

1

7

High-throughput

0.479

High

1183636

RHOU
Rho-related GTP-binding protein RhoU

1

4

High-throughput

0.479

High

1189134

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

4

High-throughput

0.479

High

1200386

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

2

High-throughput

0.479

High

1244781

NUP35
Nucleoporin NUP35

1

3

High-throughput

0.479

High

1254975

SP7
Transcription factor Sp7

1

14

High-throughput

0.479

High

1266735

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

3

High-throughput

0.479

High

1281528

FBXW7
F-box/WD repeat-containing protein 7

1

7

Small-scale

0.479

High

1304733

FEV
Protein FEV

1

19

High-throughput

0.479

High

1311945

SOX7
Transcription factor SOX-7

1

20

High-throughput

0.479

High

1332336

SOX17
Transcription factor SOX-17

1

20

High-throughput

0.479

High

1342316

GCM1
Chorion-specific transcription factor GCMa

1

1

High-throughput

0.479

High

1355818

KLF15
Krueppel-like factor 15

1

12

High-throughput

0.479

High

1357245

FZR1
Fizzy-related protein homolog

1

12

High-throughput

0.479

High

126725

DCTN6
Dynactin subunit 6

1

0

Small-scale

0.460

High

173328

S22A2
Solute carrier family 22 member 2

1

0

Small-scale

0.460

High

1086090

CDKN3
Cyclin-dependent kinase inhibitor 3

1

0

Small-scale

0.460

High

1348032

BABA2
BRISC and BRCA1-A complex member 2

1

0

Small-scale

0.460

High

1063717

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.458

High

1378227

MORC2
ATPase MORC2

1

0

Small-scale

0.458

High

595766

MAK
Serine/threonine-protein kinase MAK

1

2

Small-scale

0.445

High

1342417

ALG13
UDP-N-acetylglucosamine transferase subunit ALG13

1

13

High-throughput

0.437

High

1229696

IQCK
IQ domain-containing protein K

1

0

Small-scale

0.251

Low

1188465

ATG9A
Autophagy-related protein 9A

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024