Protein: TBCK
TBC domain-containing protein kinase-like protein (FERRY endosomal RAB5 effector complex subunit 1) (Fy-1)

Gene: TBCK
Organism: Homo sapiens
Interactions: 80
UniProt ID: Q8TEA7

Gene Ontology (top 5):
GO:0004672 - protein kinase activity
GO:0005096 - GTPase activator activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005769 - early endosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

284185

SRS10
Serine/arginine-rich splicing factor 10

1

7

High-throughput

0.691

High

463668

LYN
Tyrosine-protein kinase Lyn

1

15

High-throughput

0.691

High

557398

SRC
Proto-oncogene tyrosine-protein kinase Src

1

15

High-throughput

0.691

High

841023

FRK
Tyrosine-protein kinase FRK

1

16

High-throughput

0.691

High

997885

CSK21
Casein kinase II subunit alpha

1

20

High-throughput

0.691

High

1110513

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

16

High-throughput

0.691

High

1117417

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

13

High-throughput

0.691

High

1352219

RBM14
RNA-binding protein 14

1

3

High-throughput

0.691

High

478125

SNRPA
U1 small nuclear ribonucleoprotein A

1

5

High-throughput

0.618

High

1352217

RBPMS
RNA-binding protein with multiple splicing

1

2

High-throughput

0.575

High

477107

IL6RA
Interleukin-6 receptor subunit alpha

2

2

High-throughput

0.574

High

123780

MYO1C
Unconventional myosin-Ic

1

12

High-throughput

0.536

High

174783

SPTN2
Spectrin beta chain, non-erythrocytic 2

1

15

High-throughput

0.536

High

224752

ACTN4
Alpha-actinin-4

1

7

High-throughput

0.536

High

227927

MYO1B
Unconventional myosin-Ib

1

15

High-throughput

0.536

High

257913

DKC1
H/ACA ribonucleoprotein complex subunit DKC1

1

2

High-throughput

0.536

High

299308

FLOT1
Flotillin-1

1

5

High-throughput

0.536

High

318365

MYO1D
Unconventional myosin-Id

1

13

High-throughput

0.536

High

336459

SVIL
Supervillin

1

6

High-throughput

0.536

High

414278

P53
Cellular tumor antigen p53

1

6

High-throughput

0.536

High

418710

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

1

4

High-throughput

0.536

High

451226

NFL
Neurofilament light polypeptide

1

10

High-throughput

0.536

High

476003

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

1

4

High-throughput

0.536

High

774093

ADDA
Alpha-adducin

1

4

High-throughput

0.536

High

915138

CAZA1
F-actin-capping protein subunit alpha-1

1

5

High-throughput

0.536

High

983536

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

1

3

High-throughput

0.536

High

984211

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

3

High-throughput

0.536

High

1010332

BASP1
Brain acid soluble protein 1

1

2

High-throughput

0.536

High

1028824

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

17

High-throughput

0.536

High

1035804

KIF23
Kinesin-like protein KIF23

1

3

High-throughput

0.536

High

1058893

ZO1
Tight junction protein 1

1

12

High-throughput

0.536

High

1120774

DSG2
Desmoglein-2

1

7

High-throughput

0.536

High

1160696

DREB
Drebrin

1

3

High-throughput

0.536

High

1352216

RAD50
DNA repair protein RAD50

1

9

High-throughput

0.536

High

1352220

NEB2
Neurabin-2

1

20

High-throughput

0.536

High

1352221

PKP2
Plakophilin-2

1

12

High-throughput

0.536

High

1352222

CHM4B
Charged multivesicular body protein 4b

1

5

High-throughput

0.536

High

1352224

FERY3
Ferry endosomal RAB5 effector complex subunit 3

1

1

High-throughput

0.536

High

1352226

BCLF1
Bcl-2-associated transcription factor 1

1

6

High-throughput

0.536

High

1352231

NEB1
Neurabin-1

1

18

High-throughput

0.536

High

1352232

MYO5B
Unconventional myosin-Vb

1

5

High-throughput

0.536

High

1352234

COF2
Cofilin-2

1

4

High-throughput

0.536

High

1352235

TR150
Thyroid hormone receptor-associated protein 3

1

7

High-throughput

0.536

High

1352236

MYO5A
Unconventional myosin-Va

1

5

High-throughput

0.536

High

1251832

PPR21
Protein phosphatase 1 regulatory subunit 21

1

0

High-throughput

0.513

High

422697

A4
Amyloid-beta precursor protein

1

7

High-throughput

0.501

High

217491

E41L2
Band 4.1-like protein 2

1

11

High-throughput

0.489

High

270379

WDR1
WD repeat-containing protein 1

1

8

High-throughput

0.489

High

282017

MPPB
Mitochondrial-processing peptidase subunit beta

1

5

High-throughput

0.489

High

386012

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

6

High-throughput

0.489

High

502069

H2AZ
Histone H2A.Z

1

9

High-throughput

0.489

High

853355

CBX5
Chromobox protein homolog 5

1

2

High-throughput

0.489

High

867292

CAPZB
F-actin-capping protein subunit beta

1

3

High-throughput

0.489

High

1083681

MPPA
Mitochondrial-processing peptidase subunit alpha

1

5

High-throughput

0.489

High

1097445

CBX3
Chromobox protein homolog 3

1

2

High-throughput

0.489

High

1143204

PLEC
Plectin

1

10

High-throughput

0.489

High

1157236

AINX
Alpha-internexin

1

10

High-throughput

0.489

High

1162845

H2A2C
Histone H2A type 2-C

1

6

High-throughput

0.489

High

1164485

MIC60
MICOS complex subunit MIC60

1

1

High-throughput

0.489

High

1231632

RL7L
Ribosomal protein uL30-like

1

5

High-throughput

0.489

High

1352218

CEP63
Centrosomal protein of 63 kDa

1

10

High-throughput

0.489

High

1352223

VTA1
Vacuolar protein sorting-associated protein VTA1 homolog

1

2

High-throughput

0.489

High

1352227

TMOD3
Tropomodulin-3

1

2

High-throughput

0.489

High

1352228

ADDG
Gamma-adducin

1

4

High-throughput

0.489

High

1352229

LIMA1
LIM domain and actin-binding protein 1

1

3

High-throughput

0.489

High

1352230

ACINU
Apoptotic chromatin condensation inducer in the nucleus

1

6

High-throughput

0.489

High

1352233

COR1C
Coronin-1C

1

8

High-throughput

0.489

High

1352237

PCDBF
Protocadherin beta-15

1

1

High-throughput

0.489

High

315803

RECQ4
ATP-dependent DNA helicase Q4

1

8

High-throughput

0.479

High

989762

GNAS2
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

1

5

High-throughput

0.479

High

1207502

GNAS1
Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas

1

5

High-throughput

0.445

High

1351631

TCP1L
T-complex protein 10A homolog 1

2

0

High-throughput

0.328

High

480235

RU1C
U1 small nuclear ribonucleoprotein C

1

0

High-throughput

0.279

Low

569202

CD59
CD59 glycoprotein

1

0

High-throughput

0.279

Low

617716

XRCC1
DNA repair protein XRCC1

1

0

High-throughput

0.279

Low

829475

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

0

High-throughput

0.279

Low

1352225

MIC19
MICOS complex subunit MIC19

1

0

High-throughput

0.279

Low

560025

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

0

High-throughput

0.269

Low

1031469

IFM3
Interferon-induced transmembrane protein 3

1

0

High-throughput

0.249

Low

296727

TUSC2
Tumor suppressor candidate 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025