HitPredict

Interactor 1: KEAP1 (Q14145)
Kelch-like ECH-associated protein 1 (Cytosolic inhibitor of Nrf2) (INrf2) (Kelch-like protein 19)
Gene: KEAP1

Interactor 2: KLH12 (Q53G59)
Kelch-like protein 12 (CUL3-interacting protein 1) (DKIR homolog) (hDKIR)
Gene: KLHL12

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.41 1.00 0.647

The method score is based on:

Property Details
Experiments 32814905
Identification Methods pull down
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains BACK~BTB, BACK~Kelch_1, BTB~BTB, Kelch_1~Kelch_1
Common GO terms GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0031463 - Cul3-RING ubiquitin ligase complex
GO:0034451 - centriolar satellite
GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
and 1 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 624
Hs

1 568
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Service provided by Combinatics, Japan

Last updated: 11Aug2025