Interactor 1: WRN (Q14191)
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (DNA helicase, RecQ-like type 3) (RecQ protein-like 2) (Werner syndrome protein) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 5.6.2.4) (DNA 3'-5' helicase WRN)]
Gene: WRN
Interactor 2: WRN (Q14191)
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (DNA helicase, RecQ-like type 3) (RecQ protein-like 2) (Werner syndrome protein) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 5.6.2.4) (DNA 3'-5' helicase WRN)]
Gene: WRN
Species: Homo sapiens
Source: mint
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.52 | 1.00 | 0.724 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 10783163 |
| Identification Methods | pull down, affinity chromatography technology |
| Interaction Type | direct interaction, physical association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | DEAD~DEAD, DEAD~Helicase_C, DEAD~HRDC, DEAD~RecQ_Zn_bind, DNA_pol_A_exo1~DNA_pol_A_exo1, DNA_pol_A_exo1~HRDC, Helicase_C~Helicase_C, HRDC~Helicase_C, Helicase_C~RecQ_Zn_bind, Helicase_C~RQC, HRDC~HRDC, RQC~RecQ_Zn_bind, RQC~RQC |
| Common GO terms | GO:0000287 - magnesium ion binding GO:0000400 - four-way junction DNA binding GO:0000403 - Y-form DNA binding GO:0000405 - bubble DNA binding GO:0000723 - telomere maintenance and 51 others more... |
| Homologous interactions | 16 |
Homologous interactions
Color coding for hit scores 
Service provided by Combinatics, Japan
Last updated: 11Aug2025