HitPredict

Interactor 1: FILA2 (Q5D862)
Filaggrin-2 (FLG-2) (Intermediate filament-associated and psoriasis-susceptibility protein) (Ifapsoriasin)
Gene: FLG2

Interactor 2: ESR2 (Q92731)
Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
Gene: ESR2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	25604459
Identification Methods	tandem affinity purification
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2391 Hs			1 530
+	Hs
		369752 FILA2_HUMAN (1-2391): 0: 692: 100.00		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		1269810 CHD7_HUMAN (1784-2314): 2.13e-81: 302: 11.99		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		858022 NUP98_HUMAN (545-1218): 1.01e-78: 292: 14.16		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		370607 CHD7_HUMAN (1784-2314): 2.13e-81: 302: 11.99		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		782677 CHD7_HUMAN (1784-2314): 2.13e-81: 302: 11.99		HNF4A_HUMAN (94-502): 1.21e-107: 331: 23.30
+	Hs
		377760 CHD7_HUMAN (1784-2314): 2.13e-81: 302: 11.99		GCR_HUMAN (3-495): 1.12e-103: 330: 22.64
+	Hs
		639034 S100P_HUMAN (1-95): 1.9e-43: 155: 41.05		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		685181 S10AB_HUMAN (2-102): 3.2e-43: 155: 39.60		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		369283 S10AA_HUMAN (2-89): 2.76e-39: 143: 34.09		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		596306 FILA_HUMAN (85-1558): 5.36e-18: 94: 17.52		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		727299 NU214_HUMAN (180-979): 2.9e-17: 91.5: 14.63		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		1269345 S10AG_HUMAN (2-97): 4.33e-19: 86.3: 28.87		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		368808 S10A8_HUMAN (1-95): 8.99e-36: 133: 29.47		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		377009 S10A9_HUMAN (1-109): 6.76e-42: 151: 30.91		GCR_HUMAN (3-495): 1.12e-103: 330: 22.64
+	Hs
		377001 S10A8_HUMAN (1-95): 8.99e-36: 133: 29.47		GCR_HUMAN (3-495): 1.12e-103: 330: 22.64
+	Hs
		487803 CHD7_HUMAN (1784-2314): 2.13e-81: 302: 11.99		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Hs
		530786 S10A3_HUMAN (4-98): 1.25e-21: 93.6: 26.32		RARG_HUMAN (68-525): 2.18e-107: 330: 24.18
+	Hs
		320221 S10AG_HUMAN (2-97): 4.33e-19: 86.3: 28.87		ERR2_HUMAN (69-499): 5.86e-109: 333: 31.57
+	Hs
		487913 S10A3_HUMAN (4-98): 1.25e-21: 93.6: 26.32		RARA_HUMAN (52-505): 3.54e-105: 324: 23.74
+	Mm
		57758 ARI1A_MOUSE (122-1393): 3.68e-14: 81.3: 9.37		RARA_MOUSE (52-508): 5.87e-105: 324: 23.58