HitPredict

Interactor 1: ACTN1 (P12814)
Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1)
Gene: ACTN1

Interactor 2: ACTN2 (P35609)
Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein)
Gene: ACTN2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.74 1.00 0.863

The method score is based on:

Property Details
Experiments 25910212, 38334954, 35575683
Identification Methods two hybrid, cross-linking study, two hybrid bait and prey pooling approach, two hybrid array, validated two hybrid
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains CH~CH, CH~EF-hand_7, CH~EFhand_Ca_insen, CH~Spectrin, EF-hand_6~EF-hand_7, EF-hand_7~EFhand_Ca_insen, EFhand_Ca_insen~EFhand_Ca_insen, EFhand_Ca_insen~Spectrin, EF-hand_7~Spectrin, Spectrin~Spectrin
Common GO terms GO:0003713 - transcription coactivator activity
GO:0005178 - integrin binding
GO:0005509 - calcium ion binding
GO:0005576 - extracellular region
GO:0005829 - cytosol
and 15 others

more...
Homologous interactions 14

Homologous interactions

Color coding for hit scores

1 892
Hs

1 894
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Service provided by Combinatics, Japan

Last updated: 11Aug2025