Interactor 1: ACTN4 (O43707)
Alpha-actinin-4 (Non-muscle alpha-actinin 4)
Gene: ACTN4

Interactor 2: ACTN2 (P35609)
Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein)
Gene: ACTN2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.68 1.00 0.827

The method score is based on:

Property Details
Experiments 35575683, 38334954, 31839598
Identification Methods cross-linking study
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains CH~CH, CH~EF-hand_7, CH~EFhand_Ca_insen, CH~Spectrin, EF-hand_7~EFhand_Ca_insen, EFhand_Ca_insen~EFhand_Ca_insen, EFhand_Ca_insen~Spectrin, EF-hand_7~Spectrin, Spectrin~Spectrin
Common GO terms GO:0003713 - transcription coactivator activity
GO:0005178 - integrin binding
GO:0005509 - calcium ion binding
GO:0005576 - extracellular region
GO:0005925 - focal adhesion
and 13 others

more...

Homologous interactions 14

Homologous interactions

Color coding for hit scores

1 911
Hs

1 894
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Rn

Service provided by Combinatics, Japan

Last updated: 11Aug2025