HitPredict

Interactor 1: SART3 (Q15020)
Spliceosome associated factor 3, U4/U6 recycling protein (Squamous cell carcinoma antigen recognized by T-cells 3) (SART-3) (Tat-interacting protein of 110 kDa) (Tip110) (p110 nuclear RNA-binding protein)
Gene: SART3

Interactor 2: LSM4 (Q9Y4Z0)
U6 snRNA-associated Sm-like protein LSm4 (Glycine-rich protein) (GRP)
Gene: LSM4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.89	1.00	0.945

Property	Details
Experiments	29395067, 33961781, 28514442, 27173435, 19615732, unassigned3799
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	LSM~Lsm_interact
Common GO terms	GO:0000387 - spliceosomal snRNP assembly GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm and 1 others more... GO:0017070 - U6 snRNA binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 963 Hs			1 139
+	Hs
		1137203 SART3_HUMAN (1-963): 0: 646: 100.00		LSM2_HUMAN (1-94): 2.69e-36: 121: 28.42
+	Hs
		974744 SART3_HUMAN (1-963): 0: 646: 100.00		SMD3_HUMAN (2-108): 2.52e-28: 102: 30.84
+	Hs
		973917 SART3_HUMAN (1-963): 0: 646: 100.00		RUXF_HUMAN (3-70): 3.6e-27: 98.2: 33.82
+	Hs
		1419986 CRNL1_HUMAN (36-683): 9.92e-111: 363: 14.49		LSM2_HUMAN (1-94): 2.69e-36: 121: 28.42
+	Hs
		974040 CRNL1_HUMAN (36-683): 9.92e-111: 363: 14.49		RUXF_HUMAN (3-70): 3.6e-27: 98.2: 33.82
+	Ce
		1164846 SART3_CAEEL (73-770): 1.68e-98: 330: 21.42		LSM4_CAEEL (1-82): 2.09e-36: 122: 75.61
+	Ce
		1164689 SART3_CAEEL (73-770): 1.68e-98: 330: 21.42		SMD3_CAEEL (2-124): 3.33e-33: 115: 30.23
+	Ce
		1082595 SART3_CAEEL (73-770): 1.68e-98: 330: 21.42		SMD1_CAEEL (1-88): 8.45e-30: 106: 25.84
+	Ce
		759803 SART3_CAEEL (73-770): 1.68e-98: 330: 21.42		RUXF_CAEEL (3-80): 1.18e-27: 99.3: 25.64
+	Sc
		1036190 CLF1_YEAST (48-658): 1.82e-73: 258: 13.68		SMD1_YEAST (1-120): 8.26e-33: 114: 20.55
+	Sc
		795944 CLF1_YEAST (48-658): 1.82e-73: 258: 13.68		LSM2_YEAST (1-88): 3.47e-32: 111: 28.09
+	Sc
		847845 CLF1_YEAST (48-658): 1.82e-73: 258: 13.68		SMD3_YEAST (2-102): 4.53e-28: 100: 33.66
+	Sc
		813369 PRP39_YEAST (130-596): 3.45e-67: 239: 13.25		SMD1_YEAST (1-120): 8.26e-33: 114: 20.55
+	Hs
		321707 PRP6_HUMAN (33-561): 1.08e-50: 195: 13.42		LSM4_HUMAN (1-139): 4.82e-47: 150: 100.00
+	Hs
		685488 U2AF2_HUMAN (620-894): 8.63e-67: 233: 23.36		SMD1_HUMAN (1-94): 4.8e-32: 111: 25.26
+	Sc
		813357 PRP39_YEAST (130-596): 3.45e-67: 239: 13.25		SMD3_YEAST (2-102): 4.53e-28: 100: 33.66
+	Zm
		8309 A0A1D6ELI3_MAIZE (697-948): 2.23e-55: 207: 25.28		B6UER1_MAIZE (1-92): 4.84e-36: 120: 30.11
+	Hs
		321701 PRP6_HUMAN (33-561): 1.08e-50: 195: 13.42		LSM2_HUMAN (1-94): 2.69e-36: 121: 28.42
+	Hs
		321488 PRP6_HUMAN (33-561): 1.08e-50: 195: 13.42		SMD3_HUMAN (2-108): 2.52e-28: 102: 30.84
+	Hs
		321483 PRP6_HUMAN (33-561): 1.08e-50: 195: 13.42		RUXF_HUMAN (3-70): 3.6e-27: 98.2: 33.82