Protein: CLF1
Pre-mRNA-splicing factor CLF1 (Crooked neck-like factor 1) (PRP19-associated complex protein 77) (Synthetic lethal with CDC40 protein 3)

Gene: CLF1
Organism: Saccharomyces cerevisiae S288C
Interactions: 78
UniProt ID: Q12309

Gene Ontology (top 5):
GO:0000245 - spliceosomal complex assembly
GO:0000354 - cis assembly of pre-catalytic spliceosome
GO:0000398 - mRNA splicing, via spliceosome
GO:0000785 - chromatin
GO:0000974 - Prp19 complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

739222

PRP19
Pre-mRNA-processing factor 19

14

20

Small-scale

0.762

High

1043516

CEF1
Pre-mRNA-splicing factor CEF1

10

12

Small-scale

0.756

High

1044955

SYF1
Pre-mRNA-splicing factor SYF1

8

12

Small-scale

0.752

High

797700

NTC20
Pre-mRNA-splicing factor NTC20

7

1

Small-scale

0.750

High

1053568

SN309
Pre-mRNA-splicing factor SNT309

7

1

Small-scale

0.750

High

638092

ISY1
Pre-mRNA-splicing factor ISY1

6

6

Small-scale

0.740

High

1084185

CWC2
Pre-mRNA-splicing factor CWC2

6

9

Small-scale

0.733

High

702293

YJU2
Splicing factor YJU2

6

6

Small-scale

0.731

High

919230

SYF2
Pre-mRNA-splicing factor SYF2

5

1

Small-scale

0.717

High

700166

PRP45
Pre-mRNA-processing protein 45

5

8

Small-scale

0.713

High

1084744

PRP46
Pre-mRNA-splicing factor PRP46

5

20

Small-scale

0.713

High

664631

PRP22
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22

5

20

Small-scale

0.708

High

1055008

SP382
Pre-mRNA-splicing factor SPP382

4

3

Small-scale

0.699

High

1037766

CUS1
Cold sensitive U2 snRNA suppressor 1

4

3

Small-scale

0.692

High

751807

PRP8
Pre-mRNA-splicing factor 8

4

11

Small-scale

0.691

High

780238

SN114
Pre-mRNA-splicing factor SNU114

4

17

Small-scale

0.691

High

796474

SLT11
Pre-mRNA-splicing factor SLT11

4

6

Small-scale

0.691

High

1047397

RSE1
Pre-mRNA-splicing factor RSE1

4

4

Small-scale

0.691

High

744180

BRR2
Pre-mRNA-splicing helicase BRR2

4

20

Small-scale

0.686

High

817181

RSMB
Small nuclear ribonucleoprotein-associated protein B

4

12

Small-scale

0.686

High

892800

SF3B1
U2 snRNP component HSH155

4

12

Small-scale

0.682

High

1065581

RU2A
U2 small nuclear ribonucleoprotein A'

4

12

Small-scale

0.676

High

917513

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

3

18

High-throughput

0.671

High

919740

CWC22
Pre-mRNA-splicing factor CWC22

3

3

High-throughput

0.662

High

780871

MUD2
Splicing factor MUD2

3

1

Small-scale

0.655

High

820851

RUXG
Small nuclear ribonucleoprotein G

3

20

High-throughput

0.643

High

1065114

NCBP2
Nuclear cap-binding protein subunit 2

3

20

High-throughput

0.640

High

781594

NTR2
Pre-mRNA-splicing factor NTR2

2

1

Small-scale

0.611

High

914890

CWC23
Pre-mRNA-splicing factor CWC23

2

9

Small-scale

0.611

High

923944

CWC25
Pre-mRNA-splicing factor CWC25

2

2

High-throughput

0.611

High

1042541

CWC21
Pre-mRNA-splicing factor CWC21

2

2

High-throughput

0.601

High

628242

PRP2
Pre-mRNA-splicing factor ATP-dependent RNA helicase-like protein PRP2

2

20

High-throughput

0.584

High

847845

SMD3
Small nuclear ribonucleoprotein Sm D3

2

20

Small-scale

0.584

High

933155

RUXF
Small nuclear ribonucleoprotein F

2

12

Small-scale

0.584

High

1036190

SMD1
Small nuclear ribonucleoprotein Sm D1

2

3

Small-scale

0.584

High

1038545

SLU7
Pre-mRNA-splicing factor SLU7

2

2

Small-scale

0.584

High

1054395

SMD2
Small nuclear ribonucleoprotein Sm D2

2

6

Small-scale

0.584

High

745673

ORC2
Origin recognition complex subunit 2

1

0

Small-scale

0.549

High

1055573

URN1
Pre-mRNA-splicing factor URN1

1

1

High-throughput

0.536

High

750324

PRP40
Pre-mRNA-processing protein PRP40

1

1

Small-scale

0.527

High

528043

HSP72
Heat shock protein SSA2

2

13

High-throughput

0.504

High

590232

PRP16
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16

1

20

High-throughput

0.479

High

625146

PRP9
Pre-mRNA-splicing factor PRP9

1

4

High-throughput

0.479

High

657976

PRP28
Pre-mRNA-splicing ATP-dependent RNA helicase PRP28

1

16

Small-scale

0.479

High

672085

BUD31
Pre-mRNA-splicing factor BUD31

1

5

High-throughput

0.479

High

739286

PRP21
Pre-mRNA-splicing factor PRP21

1

6

High-throughput

0.479

High

757557

NCBP1
Nuclear cap-binding protein complex subunit 1

1

3

High-throughput

0.479

High

795944

LSM2
LSM complex subunit LSM2

1

20

Small-scale

0.479

High

818496

LSM5
LSM complex subunit LSM5

1

3

Small-scale

0.479

High

826532

IST3
U2 snRNP component IST3

1

16

High-throughput

0.479

High

826556

MSL1
U2 small nuclear ribonucleoprotein B''

1

20

High-throughput

0.479

High

829967

PRP17
Pre-mRNA-processing factor 17

1

20

High-throughput

0.479

High

863106

CWC26
Pre-mRNA-splicing factor CWC26

1

3

High-throughput

0.479

High

923757

CUS2
Cold sensitive U2 snRNA suppressor 2

1

20

Small-scale

0.479

High

924566

LSM7
LSM complex subunit LSM7

1

20

Small-scale

0.479

High

945360

LSM3
LSM complex subunit LSM3

1

20

Small-scale

0.479

High

1037094

SPP2
Pre-mRNA-splicing factor SPP2

1

1

High-throughput

0.479

High

1038775

XRN2
5'-3' exoribonuclease 2

1

4

Small-scale

0.479

High

1044030

CWC15
Pre-mRNA-splicing factor CWC15

1

1

High-throughput

0.479

High

1054950

LSM6
LSM complex subunit LSM6

1

12

Small-scale

0.479

High

1057307

RDS3
Pre-mRNA-splicing factor RDS3

1

2

High-throughput

0.479

High

1059218

PRP11
Pre-mRNA-splicing factor PRP11

1

5

High-throughput

0.479

High

1084743

RUXE
Small nuclear ribonucleoprotein E

1

6

Small-scale

0.479

High

1084745

SNU66
66 kDa U4/U6.U5 small nuclear ribonucleoprotein component

1

3

Small-scale

0.479

High

1084746

HSH49
Protein HSH49

1

10

High-throughput

0.479

High

1065542

AP3D
AP-3 complex subunit delta

1

1

High-throughput

0.437

High

546781

SSB1
Ribosome-associated molecular chaperone SSB1

1

14

High-throughput

0.407

High

752894

HSP78
Heat shock protein 78, mitochondrial

1

6

High-throughput

0.407

High

885118

RL4B
Large ribosomal subunit protein uL4B

1

4

High-throughput

0.407

High

797805

AIM4
Altered inheritance of mitochondria protein 4

1

0

High-throughput

0.279

Low

548304

FUS1
Nuclear fusion protein FUS1

1

0

High-throughput

0.265

Low

678911

CSM1
Monopolin complex subunit CSM1

1

0

Small-scale

0.265

Low

794168

GPX2
Glutathione peroxidase-like peroxiredoxin 2

1

0

High-throughput

0.265

Low

1084664

DAD1
DASH complex subunit DAD1

1

0

High-throughput

0.251

Low

1084684

CENPH
Inner kinetochore subunit MCM16

1

0

High-throughput

0.251

Low

781984

YK21
Uncharacterized protein YKR041W

1

0

High-throughput

0.249

Low

743497

SEC17
Alpha-soluble NSF attachment protein

1

0

High-throughput

0.238

Low

797702

YB40
Putative uncharacterized protein YBR190W

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025