HitPredict

Interactor 1: CRNL1 (Q9BZJ0)
Crooked neck-like protein 1 (Crooked neck homolog) (hCrn)
Gene: CRNKL1

Interactor 2: LSM2 (Q9Y333)
U6 snRNA-associated Sm-like protein LSm2 (Protein G7b) (Small nuclear ribonuclear protein D homolog) (snRNP core Sm-like protein Sm-x5)
Gene: LSM2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	29395067
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0071013 - catalytic step 2 spliceosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 848 Hs			1 95
+	Hs
		974040 CRNL1_HUMAN (1-848): 0: 583: 100.00		RUXF_HUMAN (3-71): 2.46e-23: 86.9: 31.43
+	Hs
		321701 PRP6_HUMAN (71-843): 1.84e-69: 249: 14.39		LSM2_HUMAN (1-95): 4.23e-38: 124: 100.00
+	Sc
		795944 CLF1_YEAST (184-830): 1.28e-77: 267: 36.10		LSM2_YEAST (1-95): 2.95e-31: 106: 63.16
+	Hs
		321707 PRP6_HUMAN (71-843): 1.84e-69: 249: 14.39		LSM4_HUMAN (1-87): 3.26e-32: 110: 32.58
+	Sc
		847845 CLF1_YEAST (184-830): 1.28e-77: 267: 36.10		SMD3_YEAST (2-91): 3.44e-22: 84.2: 18.89
+	Hs
		321488 PRP6_HUMAN (71-843): 1.84e-69: 249: 14.39		SMD3_HUMAN (2-88): 6.47e-24: 89.6: 20.69
+	Hs
		321483 PRP6_HUMAN (71-843): 1.84e-69: 249: 14.39		RUXF_HUMAN (3-71): 2.46e-23: 86.9: 31.43
+	Hs
		1137203 SART3_HUMAN (174-479): 4.21e-14: 78.8: 16.07		LSM2_HUMAN (1-95): 4.23e-38: 124: 100.00
+	Sp
		206001 PRP1_SCHPO (110-554): 3.72e-21: 101: 14.96		SMD1_SCHPO (1-95): 3.64e-28: 100: 31.58
+	Hs
		973951 CTR9_HUMAN (65-456): 5.76e-24: 110: 9.80		RUXF_HUMAN (3-71): 2.46e-23: 86.9: 31.43
+	Sp
		1084850 PRP1_SCHPO (110-554): 3.72e-21: 101: 14.96		SMD3_SCHPO (2-74): 1.26e-24: 90.4: 27.40
+	Hs
		1137209 SART3_HUMAN (174-479): 4.21e-14: 78.8: 16.07		LSM4_HUMAN (1-87): 3.26e-32: 110: 32.58
+	Sc
		625002 PRP6_YEAST (169-391): 3.74e-12: 72.2: 14.78		LSM2_YEAST (1-95): 2.95e-31: 106: 63.16
+	Hs
		974744 SART3_HUMAN (174-479): 4.21e-14: 78.8: 16.07		SMD3_HUMAN (2-88): 6.47e-24: 89.6: 20.69
+	Hs
		973917 SART3_HUMAN (174-479): 4.21e-14: 78.8: 16.07		RUXF_HUMAN (3-71): 2.46e-23: 86.9: 31.43
+	Hs
		974850 SYF1_HUMAN (470-769): 5.91e-12: 71.6: 18.24		SMD3_HUMAN (2-88): 6.47e-24: 89.6: 20.69
+	Sc
		847829 SYF1_YEAST (196-479): 5.95e-13: 74.9: 18.87		SMD3_YEAST (2-91): 3.44e-22: 84.2: 18.89
+	Hs
		974053 SYF1_HUMAN (470-769): 5.91e-12: 71.6: 18.24		RUXF_HUMAN (3-71): 2.46e-23: 86.9: 31.43
+	Sc
		625015 PRP6_YEAST (169-391): 3.74e-12: 72.2: 14.78		LSM4_YEAST (1-83): 6.76e-22: 85.7: 22.83
+	Sc
		625022 PRP6_YEAST (169-391): 3.74e-12: 72.2: 14.78		SMD3_YEAST (2-91): 3.44e-22: 84.2: 18.89