HitPredict

Interactor 1: GRB2 (Q60631)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: SNTA1 (Q61234)
Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Syntrophin-1)
Gene: SNTA1

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.51	1.00	0.716

Property	Details
Experiments	11551227
Identification Methods	enzyme linked immunosorbent assay, surface plasmon resonance, filter binding
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PH~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0032991 - protein-containing complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Mm			1 503
+	Oc
		101981 G1SR27_RABIT (1-217): 6.92e-74: 224: 99.54		SNTA1_RABIT (1-503): 1.36e-155: 454: 92.34
+	Hs
		924545 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		SNTA1_HUMAN (1-503): 5.14e-155: 452: 91.75
+	Hs
		789112 FRK_HUMAN (3-202): 7.94e-39: 141: 28.84		SNTB2_HUMAN (4-502): 7.65e-132: 395: 43.73
+	Hs
		411705 LCK_HUMAN (3-202): 7.66e-38: 138: 28.91		SNTB2_HUMAN (4-502): 7.65e-132: 395: 43.73
+	Hs
		411753 LCK_HUMAN (3-202): 7.66e-38: 138: 28.91		MPP7_HUMAN (33-492): 2.67e-59: 207: 13.49
+	Mm
		1141133 GRB2_MOUSE (1-217): 3.97e-74: 225: 100.00		DLG4_MOUSE (44-353): 6.52e-23: 104: 16.93
+	Hs
		924466 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		DLG4_HUMAN (44-353): 4.05e-23: 105: 16.93
+	Hs
		924701 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		LNX2_HUMAN (30-182): 6.08e-17: 85.7: 22.58
+	Hs
		924718 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		LNX1_HUMAN (14-305): 1.93e-16: 84.5: 16.61
+	Hs
		159139 HCK_HUMAN (116-215): 1.24e-11: 64.9: 19.61		CSKP_HUMAN (39-456): 2.11e-62: 220: 13.59
+	Hs
		411698 LCK_HUMAN (3-202): 7.66e-38: 138: 28.91		DLG1_HUMAN (46-353): 1.03e-21: 101: 18.04
+	Mm
		411930 LCK_MOUSE (3-202): 5.14e-38: 139: 28.44		DLG1_MOUSE (31-168): 2.25e-21: 100: 31.47
+	Hs
		442887 HCK_HUMAN (116-215): 1.24e-11: 64.9: 19.61		GOPC_HUMAN (57-163): 1.04e-35: 140: 42.48
+	Hs
		548755 VAV_HUMAN (3-60): 1.14e-15: 76.9: 43.10		LIN7C_HUMAN (77-172): 4.19e-31: 121: 37.50
+	Hs
		433490 YES_HUMAN (75-215): 5.41e-12: 66.1: 18.37		LIN7C_HUMAN (77-172): 4.19e-31: 121: 37.50
+	Hs
		412128 FYN_HUMAN (161-215): 4.88e-13: 69.2: 31.58		DLG4_HUMAN (44-353): 4.05e-23: 105: 16.93
+	Hs
		153859 YES_HUMAN (75-215): 5.41e-12: 66.1: 18.37		NHRF1_HUMAN (79-247): 8.61e-24: 104: 17.78
+	Mm
		403445 SRC_MOUSE (80-215): 1.5e-10: 61.9: 17.24		DLG4_MOUSE (44-353): 6.52e-23: 104: 16.93
+	Hs
		275210 GRAP2_HUMAN (3-55): 7.92e-11: 62.5: 39.62		LNX2_HUMAN (30-182): 6.08e-17: 85.7: 22.58
+	Hs
		275214 GRAP2_HUMAN (3-55): 7.92e-11: 62.5: 39.62		LNX1_HUMAN (14-305): 1.93e-16: 84.5: 16.61