HitPredict

Interactor 1: PWP2 (Q15269)
Periodic tryptophan protein 2 homolog
Gene: PWP2

Interactor 2: WDR75 (Q8IWA0)
WD repeat-containing protein 75 (U3 small nucleolar RNA-associated protein 17 homolog)
Gene: WDR75

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0032040 - small-subunit processome GO:0042274 - ribosomal small subunit biogenesis
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 919 Hs			1 830
+	Sc
		678444 PWP2_YEAST (1-889): 0: 558: 41.74		UTP17_YEAST (18-530): 4.05e-84: 289: 19.26
+	Hs
		1085660 PWP2_HUMAN (1-919): 0: 589: 100.00		TBL3_HUMAN (1-491): 1.58e-71: 252: 11.49
+	Hs
		1144753 PWP2_HUMAN (1-919): 0: 589: 100.00		WDR3_HUMAN (510-738): 3.7e-19: 95: 15.95
+	Dm
		1216729 Q5U0X8_DROME (1-918): 3.7e-170: 521: 45.01		Q7JQT9_DROME (108-671): 8.14e-40: 159: 11.28
+	Sc
		678361 PWP2_YEAST (1-889): 0: 558: 41.74		PWP2_YEAST (24-470): 4.22e-25: 113: 13.62
+	Sc
		678486 PWP2_YEAST (1-889): 0: 558: 41.74		UTP12_YEAST (393-613): 1.18e-23: 109: 13.33
+	Hs
		1085730 WDR3_HUMAN (1-578): 1.22e-94: 321: 13.04		TBL3_HUMAN (1-491): 1.58e-71: 252: 11.49
+	Dm
		1463899 WDS_DROME (489-792): 4.13e-60: 210: 13.07		WDS_DROME (437-660): 3.01e-42: 159: 13.16
+	Hs
		261440 TBL1X_HUMAN (411-723): 7.52e-36: 145: 16.56		TBL1R_HUMAN (329-669): 6.24e-53: 194: 10.14
+	Hs
		261437 TBL1X_HUMAN (411-723): 7.52e-36: 145: 16.56		TBL1Y_HUMAN (1-277): 4.14e-52: 192: 11.11
+	Hs
		1410246 TBL1R_HUMAN (409-723): 2.72e-34: 140: 18.56		TBL1Y_HUMAN (1-277): 4.14e-52: 192: 11.11
+	Hs
		845250 LIS1_HUMAN (96-403): 5.87e-37: 146: 14.89		LIS1_HUMAN (475-709): 2.28e-32: 132: 10.92
+	Mm
		988931 LIS1_MOUSE (96-403): 5.05e-37: 146: 14.89		LIS1_MOUSE (475-709): 1.78e-32: 132: 10.92
+	Hs
		261352 TBL1X_HUMAN (411-723): 7.52e-36: 145: 16.56		TBL1X_HUMAN (396-697): 3.04e-30: 128: 13.69
+	Hs
		845264 LIS1_HUMAN (96-403): 5.87e-37: 146: 14.89		WDR5_HUMAN (528-697): 5.41e-19: 91.2: 11.79
+	Sp
		1068486 TUP11_SCHPO (45-361): 1.05e-27: 121: 16.62		TUP12_SCHPO (473-676): 3.41e-20: 97.5: 12.74
+	Sp
		1068482 TUP11_SCHPO (45-361): 1.05e-27: 121: 16.62		TUP11_SCHPO (497-707): 2.04e-18: 91.8: 12.73
+	Hs
		1450936 NLE1_HUMAN (576-790): 2.33e-27: 118: 10.41		NLE1_HUMAN (530-700): 1.6e-18: 91.5: 8.94
+	Hs
		965276 NLE1_HUMAN (576-790): 2.33e-27: 118: 10.41		WDR5_HUMAN (528-697): 5.41e-19: 91.2: 11.79