Protein: PREX1
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1) (PtdIns(3,4,5)-dependent Rac exchanger 1)

Gene: PREX1
Organism: Homo sapiens
Interactions: 61
UniProt ID: Q8TCU6

Gene Ontology (top 5):
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005096 - GTPase activator activity
GO:0005543 - phospholipid binding
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

955401

CDC42
Cell division control protein 42 homolog

2

20

Small-scale

0.825

High

1322598

RPTOR
Regulatory-associated protein of mTOR

2

9

Small-scale

0.802

High

988545

RAC1
Ras-related C3 botulinum toxin substrate 1

2

20

Small-scale

0.799

High

839327

MTOR
Serine/threonine-protein kinase mTOR

1

7

Small-scale

0.777

High

962299

RHOA
Transforming protein RhoA

1

20

High-throughput

0.647

High

1246891

RICTR
Rapamycin-insensitive companion of mTOR

2

1

Small-scale

0.628

High

1154138

ITSN1
Intersectin-1

1

17

High-throughput

0.621

High

728341

AKT1
RAC-alpha serine/threonine-protein kinase

1

10

Small-scale

0.618

High

1151792

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.618

High

1245314

WDR59
GATOR2 complex protein WDR59

1

14

High-throughput

0.618

High

1350217

WSB2
WD repeat and SOCS box-containing protein 2

1

9

High-throughput

0.618

High

1350218

DTL
Denticleless protein homolog

1

8

High-throughput

0.618

High

396570

ESR1
Estrogen receptor

2

17

High-throughput

0.571

High

648210

NDKB
Nucleoside diphosphate kinase B

2

2

High-throughput

0.571

High

656199

PPIB
Peptidyl-prolyl cis-trans isomerase B

2

5

High-throughput

0.571

High

869926

ATPO
ATP synthase peripheral stalk subunit OSCP, mitochondrial

2

2

High-throughput

0.571

High

906568

PSMD7
26S proteasome non-ATPase regulatory subunit 7

2

3

High-throughput

0.571

High

954865

PSA6
Proteasome subunit alpha type-6

2

2

High-throughput

0.571

High

1350214

GID8
Glucose-induced degradation protein 8 homolog

2

1

High-throughput

0.571

High

1350223

PSD13
26S proteasome non-ATPase regulatory subunit 13

2

2

High-throughput

0.571

High

1254765

TRI67
Tripartite motif-containing protein 67

1

12

High-throughput

0.553

High

1350213

NLE1
Notchless protein homolog 1

1

5

High-throughput

0.553

High

771914

CBS
Cystathionine beta-synthase

2

0

High-throughput

0.547

High

1350220

NCDN
Neurochondrin

1

0

Small-scale

0.537

High

1350211

PI51A
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

1

3

High-throughput

0.536

High

1350222

TPX2
Targeting protein for Xklp2

1

4

High-throughput

0.536

High

932917

P5CS
Delta-1-pyrroline-5-carboxylate synthase

2

5

High-throughput

0.521

High

472100

MET
Hepatocyte growth factor receptor

1

19

Small-scale

0.515

High

1350212

ASPC1
Tether containing UBX domain for GLUT4

1

0

High-throughput

0.513

High

967868

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

10

Small-scale

0.508

High

333113

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

2

High-throughput

0.479

High

404254

GCR
Glucocorticoid receptor

1

17

High-throughput

0.479

High

589230

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

633753

PSB1
Proteasome subunit beta type-1

1

6

High-throughput

0.479

High

701196

PSB5
Proteasome subunit beta type-5

1

1

High-throughput

0.479

High

766715

PHB1
Prohibitin 1

1

2

High-throughput

0.479

High

963447

STXB1
Syntaxin-binding protein 1

1

2

Small-scale

0.479

High

992273

SKP1
S-phase kinase-associated protein 1

1

1

High-throughput

0.479

High

1158686

DPYL2
Dihydropyrimidinase-related protein 2

1

2

Small-scale

0.479

High

1250550

NHLC1
E3 ubiquitin-protein ligase NHLRC1

1

3

Small-scale

0.479

High

1350209

ESR2
Estrogen receptor beta

1

17

High-throughput

0.479

High

1350219

VAPA
Vesicle-associated membrane protein-associated protein A

1

2

High-throughput

0.479

High

1350221

UBQL2
Ubiquilin-2

1

5

High-throughput

0.479

High

1271297

5MP2
eIF5-mimic protein 2

1

2

High-throughput

0.470

High

332766

EPM2A
Laforin

1

0

Small-scale

0.458

High

547658

C1TC
C-1-tetrahydrofolate synthase, cytoplasmic

1

0

Small-scale

0.458

High

1204828

DCA17
DDB1- and CUL4-associated factor 17

1

0

High-throughput

0.458

High

298537

SPF30
Survival of motor neuron-related-splicing factor 30

1

3

High-throughput

0.437

High

566768

PDIA4
Protein disulfide-isomerase A4

1

5

High-throughput

0.437

High

696013

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

760972

GLYM
Serine hydroxymethyltransferase, mitochondrial

1

1

High-throughput

0.437

High

1096761

RFA4
Replication protein A 30 kDa subunit

1

1

High-throughput

0.437

High

1103492

AP3B2
AP-3 complex subunit beta-2

1

10

Small-scale

0.437

High

1127027

RBM39
RNA-binding protein 39

1

9

High-throughput

0.437

High

1350216

GAR1
H/ACA ribonucleoprotein complex subunit 1

1

1

High-throughput

0.437

High

1122906

SIM2
Single-minded homolog 2

1

0

High-throughput

0.282

High

1228309

UTP25
U3 small nucleolar RNA-associated protein 25 homolog

1

0

High-throughput

0.279

Low

768712

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

1048606

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.249

Low

1350210

MYCBP
c-Myc-binding protein

1

0

High-throughput

0.249

Low

1350215

QPCTL
Glutaminyl-peptide cyclotransferase-like protein

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025