HitPredict

Interactor 1: ITSN1 (Q15811)
Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17)
Gene: ITSN1

Interactor 2: PREX1 (Q8TCU6)
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1) (PtdIns(3,4,5)-dependent Rac exchanger 1)
Gene: PREX1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	22558309
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PH_13~RhoGEF, DEP~RhoGEF, RhoGEF~RhoGEF, RhoGEF~SOS1_NGEF_PH, RhoGEF~SH3_1, SH3_1~SOS1_NGEF_PH, RhoGEF~SH3_2, SH3_2~SOS1_NGEF_PH
Common GO terms	GO:0005085 - guanyl-nucleotide exchange factor activity GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0035556 - intracellular signal transduction GO:0051056 - regulation of small GTPase mediated signal transduction
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1721 Hs			1 1659
+	Hs
		1154182 ITSN1_HUMAN (1-1721): 0: 879: 100.00		ITSN2_HUMAN (6-519): 8.31e-94: 338: 18.83
+	Hs
		1154087 ITSN1_HUMAN (1-1721): 0: 879: 100.00		ITSN1_HUMAN (5-519): 5.04e-92: 333: 18.46
+	Hs
		1453434 ITSN2_HUMAN (1-1720): 0: 693: 55.48		ITSN2_HUMAN (6-519): 8.31e-94: 338: 18.83
+	Hs
		1206382 FGD3_HUMAN (1109-1713): 1.78e-88: 307: 16.43		FGD4_HUMAN (8-440): 2.6e-81: 287: 20.67
+	Hs
		1399582 ARHGH_HUMAN (976-1711): 3.47e-89: 325: 13.99		ECT2_HUMAN (4-442): 2.71e-74: 269: 18.60
+	Hs
		1398886 ARHG4_HUMAN (1027-1636): 7.49e-78: 275: 15.76		SPT13_HUMAN (6-458): 3.95e-91: 312: 27.80
+	Hs
		1398885 SPT13_HUMAN (1056-1643): 4.14e-76: 269: 16.86		SPT13_HUMAN (6-458): 3.95e-91: 312: 27.80
+	Mm
		839864 EPS15_MOUSE (14-410): 1.87e-37: 155: 18.38		ITSN1_MOUSE (5-519): 8e-91: 329: 18.46
+	Rn
		97303 E9PSY8_RAT (187-579): 2.37e-31: 135: 21.48		ITSN1_RAT (5-519): 5.47e-91: 330: 18.46
+	Hs
		64403 EPS15_HUMAN (508-930): 2.61e-12: 74.3: 12.03		A6H8W8_HUMAN (6-519): 9.77e-94: 338: 18.83
+	Hs
		839838 EPS15_HUMAN (508-930): 2.61e-12: 74.3: 12.03		ITSN2_HUMAN (6-519): 8.31e-94: 338: 18.83
+	Hs
		839768 EPS15_HUMAN (508-930): 2.61e-12: 74.3: 12.03		ITSN1_HUMAN (5-519): 5.04e-92: 333: 18.46
+	Hs
		299586 TRIO_HUMAN (100-1021): 2.53e-09: 64.8: 7.63		ITSN2_HUMAN (6-519): 8.31e-94: 338: 18.83
+	Mm
		1221960 EP15R_MOUSE (414-598): 4.07e-11: 70.3: 19.46		ITSN1_MOUSE (5-519): 8e-91: 329: 18.46
+	Cl
		47464 A0A8I3PJA6_CANLF (508-751): 6.05e-10: 66.6: 11.89		F1PHV6_CANLF (5-519): 3.8e-91: 330: 18.27
+	Hs
		1218376 ARHGG_HUMAN (1224-1491): 2.64e-20: 99.8: 29.18		FGD6_HUMAN (6-435): 4.05e-72: 269: 18.37
+	Mm
		60083 TRIO_MOUSE (159-1021): 6.42e-09: 63.6: 8.45		KALRN_MOUSE (38-394): 1.44e-55: 216: 22.65