HitPredict

Interactor 1: NTRK2 (Q16620)
BDNF/NT-3 growth factors receptor (EC 2.7.10.1) (GP145-TrkB) (Trk-B) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Tropomyosin-related kinase B)
Gene: NTRK2

Interactor 2: SH2B1 (Q9NRF2)
SH2B adapter protein 1 (Pro-rich, PH and SH2 domain-containing signaling mediator) (PSM) (SH2 domain-containing protein 1B)
Gene: SH2B1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	12074588
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	LRR_8~SH2, PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 822 Hs			1 756
+	Hs
		1159507 NTRK2_HUMAN (1-822): 0: 636: 100.00		SHC4_HUMAN (81-631): 3.25e-100: 324: 17.68
+	Hs
		711360 NTRK2_HUMAN (1-822): 0: 636: 100.00		SHC1_HUMAN (52-627): 8.21e-100: 321: 17.54
+	Hs
		1102330 NTRK2_HUMAN (1-822): 0: 636: 100.00		GRB10_HUMAN (82-618): 2.93e-92: 302: 12.05
+	Hs
		1159521 NTRK2_HUMAN (1-822): 0: 636: 100.00		SHC3_HUMAN (80-629): 9.59e-88: 290: 15.73
+	Rn
		1208120 NTRK2_RAT (1-822): 0: 620: 93.55		SHC1_RAT (163-627): 2.85e-92: 298: 17.68
+	Hs
		440578 NTRK2_HUMAN (1-822): 0: 636: 100.00		FYN_HUMAN (401-742): 7.61e-74: 251: 13.87
+	Hs
		619066 NTRK2_HUMAN (1-822): 0: 636: 100.00		PLCG1_HUMAN (451-753): 3.43e-69: 249: 17.19
+	Mm
		581991 NTRK2_MOUSE (1-822): 0: 629: 93.92		PLCG1_MOUSE (451-753): 4.46e-69: 249: 17.19
+	Rn
		531976 NTRK2_RAT (1-822): 0: 620: 93.55		PLCG1_RAT (451-753): 2.2e-69: 250: 17.50
+	Hs
		711358 NTRK3_HUMAN (17-822): 7.97e-176: 529: 52.85		SHC1_HUMAN (52-627): 8.21e-100: 321: 17.54
+	Mm
		1022213 NTRK1_MOUSE (45-822): 1.35e-174: 525: 46.52		SHC1_MOUSE (52-627): 7.6e-100: 321: 17.07
+	Rn
		776778 NTRK1_RAT (24-822): 8.19e-174: 523: 46.98		SHC1_RAT (163-627): 2.85e-92: 298: 17.68
+	Mm
		1190019 NTRK1_MOUSE (45-822): 1.35e-174: 525: 46.52		SHC3_MOUSE (195-629): 1.15e-84: 278: 16.36
+	Rn
		776773 NTRK1_RAT (24-822): 8.19e-174: 523: 46.98		SH2B3_RAT (400-754): 5.49e-78: 256: 30.03
+	Hs
		619064 NTRK3_HUMAN (17-822): 7.97e-176: 529: 52.85		PLCG1_HUMAN (451-753): 3.43e-69: 249: 17.19
+	Mm
		1190020 NTRK1_MOUSE (45-822): 1.35e-174: 525: 46.52		PLCG1_MOUSE (451-753): 4.46e-69: 249: 17.19
+	Hs
		987670 NTRK2_HUMAN (1-822): 0: 636: 100.00		GRB2_HUMAN (517-646): 2.76e-16: 80.5: 18.46
+	Hs
		599293 NTRK3_HUMAN (17-822): 7.97e-176: 529: 52.85		PLCG2_HUMAN (507-753): 4.82e-47: 183: 17.11
+	Hs
		987668 NTRK3_HUMAN (17-822): 7.97e-176: 529: 52.85		GRB2_HUMAN (517-646): 2.76e-16: 80.5: 18.46
+	Rn
		776775 NTRK1_RAT (24-822): 8.19e-174: 523: 46.98		GRB2_RAT (517-646): 2.76e-16: 80.5: 18.46