Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.95 1.00 0.975

The method score is based on:

Property Details
Experiments 26151834, 16169070, 25253489, 31839598, 21360678, 12853476, 8289821, 21460846, 25036637
Identification Methods pull down, two hybrid, cross-linking study, affinity chromatography technology, molecular sieving, blue native page, anti tag coimmunoprecipitation, two hybrid pooling approach, luminescence based mammalian interactome mapping
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains HATPase_c_3~HATPase_c_3, HATPase_c_3~HSP90, HSP90~HSP90
Common GO terms GO:0001764 - neuron migration
GO:0002134 - UTP binding
GO:0002135 - CTP binding
GO:0002218 - activation of innate immune response
GO:0002230 - positive regulation of defense response to virus by host
and 89 others

more...

Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 732
Hs

1 732
+ Mm
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ At
+ Hs
+ Ce
+ Sp
+ Ca
+ Sc
+ Hs
+ Sc
+ Hs
+ Hs
+ Hs
+ Dm

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Last updated: 11Aug2025