HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.987

The method score is based on:

Property Details
Experiments 26496610, 33961781, 35271311, 35043518, 34349018, 35235311, 37071682, 36652389, 35575683, 38334954, 39358380, 31839598, 39422127, 34535262, 40437099, 19875381, 21360678, 20353823, 25036637, unassigned3799
Identification Methods affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains HATPase_c_3~HATPase_c_3, HATPase_c_3~HSP90, HSP90~HSP90
Common GO terms GO:0003723 - RNA binding
GO:0005524 - ATP binding
GO:0005576 - extracellular region
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
and 37 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 732
Hs

1 724
+ Hs
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+ Mm
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+ Hs
+ At
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+ Ce
+ Hs
+ Dm
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+ Ca
+ Sp
+ Sc
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+ Hs

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Last updated: 11Aug2025