HitPredict

Interactor 1: ARVC (O00192)
Splicing regulator ARVCF (Armadillo repeat protein deleted in velo-cardio-facial syndrome)
Gene: ARVCF

Interactor 2: CAD15 (P55291)
Cadherin-15 (Cadherin-14) (Muscle cadherin) (M-cadherin)
Gene: CDH15

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.740

Property	Details
Experiments	11058098
Identification Methods	two hybrid, affinity chromatography technology, pull down
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Arm~CADH_Y-type_LIR
Common GO terms	GO:0005886 - plasma membrane GO:0005912 - adherens junction GO:0007155 - cell adhesion GO:0007043 - cell-cell junction assembly GO:0045296 - cadherin binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 962 Hs			1 814
+	Mm
		702740 ARVC_MOUSE (1-962): 0: 879: 91.60		CAD15_MOUSE (42-782): 0: 732: 86.56
+	Hs
		119759 ARVC_HUMAN (1-962): 0: 869: 100.00		CADH5_HUMAN (38-781): 0: 640: 31.98
+	Mm
		677630 CTND1_MOUSE (1-933): 0: 773: 46.39		CADH5_MOUSE (1-781): 0: 656: 31.09
+	Hs
		239052 CTND1_HUMAN (1-933): 0: 750: 46.14		CADH3_HUMAN (26-781): 0: 658: 39.48
+	Hs
		239063 CTND1_HUMAN (1-933): 0: 750: 46.14		CADH5_HUMAN (38-781): 0: 640: 31.98
+	Hs
		119763 ARVC_HUMAN (1-962): 0: 869: 100.00		CAD12_HUMAN (2-473): 6.42e-87: 294: 22.40
+	Hs
		119762 ARVC_HUMAN (1-962): 0: 869: 100.00		CADH8_HUMAN (2-473): 5.62e-85: 289: 21.64
+	Mm
		544706 ARVC_MOUSE (1-962): 0: 879: 91.60		CADH2_MOUSE (2-473): 7.98e-67: 241: 20.12
+	Hs
		119755 ARVC_HUMAN (1-962): 0: 869: 100.00		CADH2_HUMAN (2-473): 9.65e-65: 235: 19.52
+	Hs
		239096 CTND1_HUMAN (1-933): 0: 750: 46.14		CADH8_HUMAN (2-473): 5.62e-85: 289: 21.64
+	Hs
		239165 CTND1_HUMAN (1-933): 0: 750: 46.14		CAD24_HUMAN (3-473): 1.93e-77: 269: 22.52
+	Mm
		544697 CTND1_MOUSE (1-933): 0: 773: 46.39		CADH2_MOUSE (2-473): 7.98e-67: 241: 20.12
+	Hs
		119753 ARVC_HUMAN (1-962): 0: 869: 100.00		CADH1_HUMAN (2-368): 7.38e-34: 141: 16.93
+	Hs
		239048 CTND1_HUMAN (1-933): 0: 750: 46.14		CADH2_HUMAN (2-473): 9.65e-65: 235: 19.52
+	Mm
		454953 ARVC_MOUSE (1-962): 0: 879: 91.60		CADH1_MOUSE (7-238): 1.21e-17: 90: 18.55
+	Hs
		239034 CTND1_HUMAN (1-933): 0: 750: 46.14		CADH1_HUMAN (2-368): 7.38e-34: 141: 16.93
+	Mm
		454947 CTND1_MOUSE (1-933): 0: 773: 46.39		CADH1_MOUSE (7-238): 1.21e-17: 90: 18.55
+	Hs
		239097 CTND1_HUMAN (1-933): 0: 750: 46.14		CAD11_HUMAN (2-146): 2.99e-10: 66.1: 16.45
+	Hs
		971080 PKP3_HUMAN (19-852): 9.74e-160: 491: 26.20		DSC2_HUMAN (15-478): 9.22e-54: 202: 18.84
+	Hs
		522286 PKP3_HUMAN (19-852): 9.74e-160: 491: 26.20		CADH1_HUMAN (2-368): 7.38e-34: 141: 16.93