HitPredict

Interactor 1: KLH12 (Q53G59)
Kelch-like protein 12 (CUL3-interacting protein 1) (DKIR homolog) (hDKIR)
Gene: KLHL12

Interactor 2: KLH12 (Q53G59)
Kelch-like protein 12 (CUL3-interacting protein 1) (DKIR homolog) (hDKIR)
Gene: KLHL12

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.95 1.00 0.976

The method score is based on:

Property Details
Experiments 25416956, 16189514, 27716508, 27107012, 30190310, 32296183, 32814905, 37495603, unassigned1304
Identification Methods two hybrid, affinity chromatography technology, pull down, two hybrid array, barcode fusion genetics two hybrid, validated two hybrid, two hybrid prey pooling approach, two hybrid pooling approach
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains BACK~BTB, BACK~Kelch_1, BTB~BTB, Kelch_1~Kelch_1
Common GO terms GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006513 - protein monoubiquitination
GO:0006888 - endoplasmic reticulum to Golgi vesicle-mediated transport
GO:0014029 - neural crest formation
and 10 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 568
Hs

1 568
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Service provided by Combinatics, Japan

Last updated: 11Aug2025