HitPredict

Interactor 1: CAND1 (Q86VP6)
Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (TBP-interacting protein of 120 kDa A) (TBP-interacting protein 120A) (p120 CAND1)
Gene: CAND1

Interactor 2: CUL5 (Q93034)
Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1)
Gene: CUL5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	1.00	0.960

Property	Details
Experiments	28514442, 31253590, 36423380, 21249194, 22405651, 21145461, 12504025
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Cullin~TIP120
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1230 Hs			1 780
+	Hs
		1041947 CAND1_HUMAN (1-1230): 0: 922: 100.00		CUL3_HUMAN (8-780): 0: 754: 22.96
+	Hs
		1041074 CAND1_HUMAN (1-1230): 0: 922: 100.00		CUL1_HUMAN (11-780): 0: 748: 27.84
+	Mm
		1169688 CAND1_MOUSE (1-1230): 0: 920: 99.43		CUL1_MOUSE (11-780): 0: 748: 27.84
+	Hs
		1043084 CAND1_HUMAN (1-1230): 0: 922: 100.00		CUL4A_HUMAN (16-780): 0: 744: 24.48
+	Hs
		1043440 CAND1_HUMAN (1-1230): 0: 922: 100.00		CUL4B_HUMAN (16-780): 0: 736: 25.39
+	Hs
		1041383 CAND1_HUMAN (1-1230): 0: 922: 100.00		CUL2_HUMAN (6-780): 0: 699: 26.36
+	Mm
		1169706 CAND2_MOUSE (1-1230): 0: 841: 60.47		CUL1_MOUSE (11-780): 0: 748: 27.84
+	Hs
		256749 CAND2_HUMAN (1-1230): 0: 830: 62.25		CUL3_HUMAN (8-780): 0: 754: 22.96
+	Hs
		256748 CAND2_HUMAN (1-1230): 0: 830: 62.25		CUL1_HUMAN (11-780): 0: 748: 27.84
+	Dm
		1213848 CAND1_DROME (1-1230): 0: 781: 57.85		Q8IP45_DROME (5-780): 0: 736: 22.73
+	Dm
		1097204 CAND1_DROME (1-1230): 0: 781: 57.85		CUL1_DROME (3-780): 0: 694: 25.99
+	At
		1226078 CAND1_ARATH (4-1218): 0: 734: 42.73		CUL1_ARATH (8-780): 0: 721: 24.34
+	At
		1226075 CAND1_ARATH (4-1218): 0: 734: 42.73		CUL4_ARATH (16-780): 0: 694: 24.09
+	Ce
		105745 CAND1_CAEEL (4-1222): 0: 613: 35.74		CUL1_CAEEL (4-780): 0: 694: 25.34
+	Ce
		105750 CAND1_CAEEL (4-1222): 0: 613: 35.74		CUL5_CAEEL (13-780): 0: 676: 50.78
+	Ce
		105747 CAND1_CAEEL (4-1222): 0: 613: 35.74		CUL3_CAEEL (17-780): 0: 658: 21.47
+	Ce
		105746 CAND1_CAEEL (4-1222): 0: 613: 35.74		CUL2_CAEEL (7-780): 0: 646: 24.85
+	Ce
		105749 CAND1_CAEEL (4-1222): 0: 613: 35.74		CUL6_CAEEL (13-780): 0: 624: 24.97
+	Sp
		142920 CAND1_SCHPO (9-1222): 1.44e-124: 416: 19.45		CUL1_SCHPO (3-780): 0: 680: 24.97
+	Hs
		163605 BTAF1_HUMAN (32-1121): 7.24e-85: 307: 11.67		CUL3_HUMAN (8-780): 0: 754: 22.96