HitPredict

Interactor 1: FCSD1 (Q86WN1)
F-BAR and double SH3 domains protein 1 (Protein nervous wreck 2) (NWK2)
Gene: FCHSD1

Interactor 2: ITSN2 (Q9NZM3)
Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein)
Gene: ITSN2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	0.80	0.677

Property	Details
Experiments	19041431, 22558309
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	FCH~SH3_9, RhoGEF~SH3_9, SH3_2~SH3_9, SH3_9~SH3_9
Common GO terms	-
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 690 Hs			1 1697
+	Hs
		298006 FCSD2_HUMAN (1-680): 1.31e-81: 276: 36.30		ITSN2_HUMAN (1-1697): 0: 969: 100.00
+	Hs
		297971 FCSD2_HUMAN (1-680): 1.31e-81: 276: 36.30		ITSN1_HUMAN (2-1693): 0: 863: 56.23
+	Hs
		1349275 ITSN2_HUMAN (145-685): 2.17e-22: 105: 10.72		ITSN2_HUMAN (1-1697): 0: 969: 100.00
+	Hs
		1078897 FNBP1_HUMAN (14-614): 3.84e-51: 189: 13.31		ITSN1_HUMAN (2-1693): 0: 863: 56.23
+	Hs
		1001577 FCHO2_HUMAN (11-617): 3.2e-41: 163: 11.61		ITSN1_HUMAN (2-1693): 0: 863: 56.23
+	Hs
		1078919 ITSN2_HUMAN (145-685): 2.17e-22: 105: 10.72		ITSN1_HUMAN (2-1693): 0: 863: 56.23
+	Hs
		1078828 ITSN1_HUMAN (12-631): 3.75e-22: 104: 11.96		ITSN1_HUMAN (2-1693): 0: 863: 56.23
+	Hs
		279897 ITSN2_HUMAN (145-685): 2.17e-22: 105: 10.72		TRIO_HUMAN (205-1561): 3.77e-74: 277: 10.84
+	Hs
		1078876 ITSN1_HUMAN (12-631): 3.75e-22: 104: 11.96		PREX1_HUMAN (1167-1594): 2.68e-68: 257: 19.20
+	Hs
		1001598 FCHO2_HUMAN (11-617): 3.2e-41: 163: 11.61		EP15R_HUMAN (3-509): 1.83e-36: 152: 16.67
+	Hs
		548628 VAV_HUMAN (1-606): 6.31e-63: 226: 14.20		VAV_HUMAN (526-1189): 1.23e-13: 78.3: 13.15
+	Hs
		787902 FCHO2_HUMAN (11-617): 3.2e-41: 163: 11.61		EPS15_HUMAN (7-478): 5.01e-32: 138: 16.98
+	Hs
		1349279 ITSN2_HUMAN (145-685): 2.17e-22: 105: 10.72		EP15R_HUMAN (3-509): 1.83e-36: 152: 16.67
+	Hs
		61738 A6H8W8_HUMAN (190-685): 2.65e-22: 105: 12.62		EP15R_HUMAN (3-509): 1.83e-36: 152: 16.67
+	Hs
		1078923 ITSN1_HUMAN (12-631): 3.75e-22: 104: 11.96		EP15R_HUMAN (3-509): 1.83e-36: 152: 16.67
+	Hs
		61732 A6H8W8_HUMAN (190-685): 2.65e-22: 105: 12.62		EPS15_HUMAN (7-478): 5.01e-32: 138: 16.98
+	Hs
		787985 ITSN2_HUMAN (145-685): 2.17e-22: 105: 10.72		EPS15_HUMAN (7-478): 5.01e-32: 138: 16.98
+	Hs
		787920 ITSN1_HUMAN (12-631): 3.75e-22: 104: 11.96		EPS15_HUMAN (7-478): 5.01e-32: 138: 16.98
+	Dm
		91151 M9ND00_DROME (389-615): 2.24e-37: 152: 20.80		E3CTP7_DROME (216-327): 1.05e-15: 85.2: 34.82