HitPredict

Interactor 1: LRRK2 (Q5S007)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)
Gene: LRRK2

Interactor 2: DAPP1 (Q9UN19)
Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide (hDAPP1) (B lymphocyte adapter protein Bam32) (B-cell adapter molecule of 32 kDa)
Gene: DAPP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	24947832
Identification Methods	protein array
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	LRR_8~SH2, PH~Pkinase
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2527 Hs			1 280
+	Hs
		362306 LRRK2_HUMAN (1-2527): 0: 3019: 100.00		ABL1_HUMAN (8-280): 4.15e-50: 179: 17.61
+	Hs
		840966 LRRK2_HUMAN (1-2527): 0: 3019: 100.00		ABL2_HUMAN (8-280): 1.22e-49: 177: 17.25
+	Hs
		72374 LRRK2_HUMAN (1-2527): 0: 3019: 100.00		A9UEZ6_HUMAN (8-280): 1.71e-48: 174: 16.55
+	Hs
		69578 LRRK2_HUMAN (1-2527): 0: 3019: 100.00		A8K3B6_HUMAN (10-280): 7.37e-42: 150: 13.43
+	Hs
		1053677 LRRK2_HUMAN (1-2527): 0: 3019: 100.00		PTN11_HUMAN (35-225): 1.7e-29: 118: 22.28
+	Hs
		1195623 LRRK2_HUMAN (1-2527): 0: 3019: 100.00		Q4LE43_HUMAN (4-184): 1.64e-22: 99.1: 23.00
+	Hs
		557157 MATK_HUMAN (1683-2160): 2.38e-106: 352: 20.83		SRC_HUMAN (4-280): 1.33e-56: 191: 18.77
+	Rn
		740516 CSK_RAT (1722-2140): 1.32e-102: 339: 21.20		SRC_RAT (4-280): 1.06e-56: 192: 18.77
+	Hs
		557151 CSK_HUMAN (1722-2140): 1.85e-102: 339: 20.74		SRC_HUMAN (4-280): 1.33e-56: 191: 18.77
+	Hs
		440423 CSK_HUMAN (1722-2140): 1.85e-102: 339: 20.74		FYN_HUMAN (4-280): 3.63e-56: 190: 19.80
+	Hs
		439980 CSK_HUMAN (1722-2140): 1.85e-102: 339: 20.74		LCK_HUMAN (3-280): 8.14e-53: 181: 20.07
+	Hs
		834151 CSK_HUMAN (1722-2140): 1.85e-102: 339: 20.74		FRK_HUMAN (3-280): 1.08e-52: 180: 19.38
+	Hs
		834150 MATK_HUMAN (1683-2160): 2.38e-106: 352: 20.83		CSK_HUMAN (10-280): 9.76e-42: 150: 13.43
+	Mm
		834245 CSK_MOUSE (1722-2140): 1.21e-102: 340: 21.20		CSK_MOUSE (10-280): 5.62e-45: 159: 15.14
+	Mm
		593629 BLK_MOUSE (1794-2134): 5.24e-84: 288: 27.45		Q91YX7_MOUSE (18-276): 4.47e-59: 203: 24.16
+	Hs
		834149 CSK_HUMAN (1722-2140): 1.85e-102: 339: 20.74		CSK_HUMAN (10-280): 9.76e-42: 150: 13.43
+	Hs
		635685 CSK_HUMAN (1722-2140): 1.85e-102: 339: 20.74		RASA1_HUMAN (17-137): 1.88e-23: 101: 25.81
+	Mm
		593628 BLK_MOUSE (1794-2134): 5.24e-84: 288: 27.45		PLCG2_MOUSE (4-198): 3.53e-22: 97.9: 20.83
+	Hs
		362304 LRRK1_HUMAN (866-1174): 1.81e-33: 144: 15.41		ABL1_HUMAN (8-280): 4.15e-50: 179: 17.61
+	Hs
		840886 LRRK1_HUMAN (866-1174): 1.81e-33: 144: 15.41		TEC_HUMAN (9-280): 5.63e-44: 159: 15.23