HitPredict

Interactor 1: Q5VU62 (Q5VU62)
TPM3 protein (cDNA FLJ32435 fis, clone SKMUS2001287, highly similar to Tropomyosin alpha-3 chain)
Gene: TPM3

Interactor 2: Q5VU62 (Q5VU62)
TPM3 protein (cDNA FLJ32435 fis, clone SKMUS2001287, highly similar to Tropomyosin alpha-3 chain)
Gene: TPM3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	25416956
Identification Methods	two hybrid array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Tropomyosin~Tropomyosin
Common GO terms	GO:0003779 - actin binding
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 158 Hs			1 158
+	Gg
		407555 TPM1_CHICK (1-158): 6.55e-45: 150: 94.30		TPM1_CHICK (1-158): 6.55e-45: 150: 94.30
+	Rn
		415085 TPM1_RAT (1-158): 2.34e-44: 149: 91.14		TPM1_RAT (1-158): 2.34e-44: 149: 91.14
+	Hs
		447637 TPM3_HUMAN (1-158): 1.14e-44: 149: 100.00		TPM3_HUMAN (1-158): 1.14e-44: 149: 100.00
+	Mm
		946684 TPM1_MOUSE (1-158): 2.34e-44: 149: 91.14		TPM1_MOUSE (1-158): 2.34e-44: 149: 91.14
+	Hs
		447646 TPM3_HUMAN (1-158): 1.14e-44: 149: 100.00		TPM1_HUMAN (1-158): 2.84e-44: 148: 90.51
+	Hs
		482817 TPM1_HUMAN (1-158): 2.84e-44: 148: 90.51		TPM1_HUMAN (1-158): 2.84e-44: 148: 90.51
+	Gg
		407556 TPM1_CHICK (1-158): 6.55e-45: 150: 94.30		TPM2_CHICK (1-158): 1.3e-42: 144: 87.34
+	Mm
		946693 TPM1_MOUSE (1-158): 2.34e-44: 149: 91.14		TPM4_MOUSE (1-158): 7.7e-42: 141: 73.42
+	Hs
		447735 TPM3_HUMAN (1-158): 1.14e-44: 149: 100.00		TPM4_HUMAN (1-158): 5.98e-39: 134: 76.58
+	Hs
		482880 TPM1_HUMAN (1-158): 2.84e-44: 148: 90.51		TPM4_HUMAN (1-158): 5.98e-39: 134: 76.58
+	Hs
		482989 TPM1_HUMAN (1-158): 2.84e-44: 148: 90.51		V9HW56_HUMAN (1-158): 5.98e-39: 134: 76.58
+	Hs
		447640 TPM3_HUMAN (1-158): 1.14e-44: 149: 100.00		TPM2_HUMAN (1-158): 5.87e-37: 129: 86.71
+	Hs
		464098 TPM1_HUMAN (1-158): 2.84e-44: 148: 90.51		TPM2_HUMAN (1-158): 5.87e-37: 129: 86.71
+	Hs
		464144 TPM4_HUMAN (1-158): 5.98e-39: 134: 76.58		TPM2_HUMAN (1-158): 5.87e-37: 129: 86.71