HitPredict

Interactor 1: TPM1 (P09493)
Tropomyosin alpha-1 chain (Alpha-tropomyosin) (Tropomyosin-1)
Gene: TPM1

Interactor 2: V9HW56 (V9HW56)
Epididymis secretory protein Li 108
Gene: HEL-S-108

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	25416956
Identification Methods	two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Tropomyosin~Tropomyosin
Common GO terms	GO:0051015 - actin filament binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 284 Hs			1 248
+	Gg
		407555 TPM1_CHICK (1-284): 5.64e-45: 155: 95.78		TPM1_CHICK (4-248): 2.96e-49: 165: 69.39
+	Rn
		415085 TPM1_RAT (1-284): 1.73e-44: 153: 99.65		TPM1_RAT (4-248): 1.11e-48: 163: 68.57
+	Hs
		482817 TPM1_HUMAN (1-284): 2.36e-44: 153: 100.00		TPM1_HUMAN (4-248): 1.44e-48: 163: 68.16
+	Mm
		946684 TPM1_MOUSE (1-284): 1.73e-44: 153: 99.65		TPM1_MOUSE (4-248): 1.11e-48: 163: 68.57
+	Mm
		946693 TPM1_MOUSE (1-284): 1.73e-44: 153: 99.65		TPM4_MOUSE (1-248): 1.79e-48: 162: 95.97
+	Gg
		407556 TPM1_CHICK (1-284): 5.64e-45: 155: 95.78		TPM2_CHICK (4-248): 2.32e-46: 157: 68.98
+	Hs
		447646 TPM1_HUMAN (1-284): 2.36e-44: 153: 100.00		TPM3_HUMAN (4-248): 6.5e-47: 159: 69.39
+	Hs
		447637 TPM3_HUMAN (1-284): 1.02e-43: 152: 91.20		TPM3_HUMAN (4-248): 6.5e-47: 159: 69.39
+	Hs
		482880 TPM1_HUMAN (1-284): 2.36e-44: 153: 100.00		TPM4_HUMAN (1-248): 5.58e-47: 158: 100.00
+	Hs
		447735 TPM3_HUMAN (1-284): 1.02e-43: 152: 91.20		TPM4_HUMAN (1-248): 5.58e-47: 158: 100.00
+	Hs
		1218085 Q5VU62_HUMAN (127-284): 3.38e-44: 149: 90.51		Q5VU62_HUMAN (91-248): 4.81e-45: 150: 76.58
+	Hs
		464098 TPM1_HUMAN (1-284): 2.36e-44: 153: 100.00		TPM2_HUMAN (4-248): 5.06e-42: 146: 69.39
+	Hs
		447640 TPM3_HUMAN (1-284): 1.02e-43: 152: 91.20		TPM2_HUMAN (4-248): 5.06e-42: 146: 69.39
+	Hs
		462828 LAMB1_HUMAN (1-248): 3.32e-37: 141: 23.44		TPM2_HUMAN (4-248): 5.06e-42: 146: 69.39
+	Hs
		462837 LAMC1_HUMAN (2-284): 2.67e-53: 188: 18.34		LAMB1_HUMAN (4-243): 4.91e-14: 73.5: 16.25
+	Dm
		447909 TPM1_DROME (1-281): 3.08e-56: 186: 44.78		TPM1_DROME (7-241): 5.07e-09: 57.7: 24.68
+	Hs
		447639 TPM3_HUMAN (1-284): 1.02e-43: 152: 91.20		LAMB1_HUMAN (4-243): 4.91e-14: 73.5: 16.25