HitPredict

Interactor 1: KIBRA (Q8IX03)
Protein KIBRA (HBeAg-binding protein 3) (Kidney and brain protein) (KIBRA) (WW domain-containing protein 1)
Gene: WWC1

Interactor 2: ARRD1 (Q8N5I2)
Arrestin domain-containing protein 1 (Alpha-arrestin 1)
Gene: ARRDC1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1113 Hs			1 433
+	Dm
		1249327 KIBRA_DROME (4-1111): 0: 595: 31.01		Q8SYU5_DROME (5-415): 1.6e-90: 283: 18.01
+	Dm
		1365482 KIBRA_DROME (4-1111): 0: 595: 31.01		Q9VGU4_DROME (6-421): 1.2e-75: 246: 20.05
+	Hs
		48451 ESYT2_HUMAN (367-791): 7.28e-70: 254: 15.27		ARRD3_HUMAN (1-373): 1.85e-94: 292: 20.81
+	Hs
		1234602 NED4L_HUMAN (656-807): 2.04e-33: 141: 15.09		ARRD1_HUMAN (1-433): 5.38e-131: 386: 100.00
+	Dm
		115614 M9PFK2_DROME (674-1015): 8.35e-46: 181: 11.70		Q9VI00_DROME (5-389): 3.03e-102: 312: 19.62
+	Dm
		1367624 NEDD4_DROME (674-1015): 3.91e-45: 179: 11.60		Q9VI00_DROME (5-389): 3.03e-102: 312: 19.62
+	Dm
		115611 M9PFK2_DROME (674-1015): 8.35e-46: 181: 11.70		Q8SYU5_DROME (5-415): 1.6e-90: 283: 18.01
+	Dm
		1249345 NEDD4_DROME (674-1015): 3.91e-45: 179: 11.60		Q8SYU5_DROME (5-415): 1.6e-90: 283: 18.01
+	Dm
		115613 M9PFK2_DROME (674-1015): 8.35e-46: 181: 11.70		Q9VHZ7_DROME (7-293): 5.87e-81: 260: 23.30
+	Dm
		1367606 NEDD4_DROME (674-1015): 3.91e-45: 179: 11.60		Q9VHZ7_DROME (7-293): 5.87e-81: 260: 23.30
+	Hs
		1252808 NED4L_HUMAN (656-807): 2.04e-33: 141: 15.09		ARRD2_HUMAN (2-371): 6.72e-95: 293: 22.36
+	Hs
		1285052 NED4L_HUMAN (656-807): 2.04e-33: 141: 15.09		ARRD3_HUMAN (1-373): 1.85e-94: 292: 20.81
+	Dm
		115612 M9PFK2_DROME (674-1015): 8.35e-46: 181: 11.70		Q9VGU4_DROME (6-421): 1.2e-75: 246: 20.05
+	Dm
		1366431 NEDD4_DROME (674-1015): 3.91e-45: 179: 11.60		Q9VGU4_DROME (6-421): 1.2e-75: 246: 20.05
+	Hs
		1285083 WWOX_HUMAN (5-113): 1.68e-31: 130: 29.46		ARRD3_HUMAN (1-373): 1.85e-94: 292: 20.81
+	Hs
		1299631 NED4L_HUMAN (656-807): 2.04e-33: 141: 15.09		TXNIP_HUMAN (3-360): 7.93e-86: 269: 21.09
+	Hs
		1241907 NED4L_HUMAN (656-807): 2.04e-33: 141: 15.09		ARRD4_HUMAN (2-361): 1.4e-82: 261: 24.07
+	Hs
		686006 SYT2_HUMAN (661-794): 3.54e-40: 156: 21.64		ARRB2_HUMAN (22-320): 9.21e-72: 233: 16.62
+	Hs
		686035 ITCH_HUMAN (2-164): 5.57e-30: 130: 22.94		ARRB2_HUMAN (22-320): 9.21e-72: 233: 16.62
+	Mm
		1208049 ITCH_MOUSE (4-164): 5.33e-30: 130: 22.62		ARRB2_MOUSE (22-320): 2.4e-69: 227: 16.29