Protein: TSN6
Tetraspanin-6 (Tspan-6) (A15 homolog) (Putative NF-kappa-B-activating protein 321) (T245 protein) (Tetraspanin TM4-D) (Transmembrane 4 superfamily member 6)

Gene: TSN6, TSPAN6
Organism: Homo sapiens
Interactions: 63
UniProt ID: O43657

Gene Ontology (top 5):
GO:0005886 - plasma membrane
GO:0039532 - negative regulation of cytoplasmic pattern recognition receptor signaling pathway
GO:0043123 - positive regulation of canonical NF-kappaB signal transduction
GO:0043124 - negative regulation of canonical NF-kappaB signal transduction
GO:0070062 - extracellular exosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

222340

TSN15
Tetraspanin-15

1

18

High-throughput

0.691

High

222393

CLC5A
C-type lectin domain family 5 member A

3

13

High-throughput

0.667

High

222370

CC50B
Cell cycle control protein 50B

2

2

High-throughput

0.628

High

222375

LYPD4
Ly6/PLAUR domain-containing protein 4

2

2

High-throughput

0.628

High

222377

GP141
Probable G-protein coupled receptor 141

2

14

High-throughput

0.628

High

222381

SPA12
Serpin A12

2

5

High-throughput

0.628

High

222389

ASIC4
Acid-sensing ion channel 4

2

1

High-throughput

0.628

High

222362

EVA1C
Protein eva-1 homolog C

3

5

High-throughput

0.609

High

222338

VNN2
Pantetheine hydrolase VNN2

2

0

High-throughput

0.602

High

222365

TNR17
Tumor necrosis factor receptor superfamily member 17

2

0

High-throughput

0.602

High

222379

LRRT1
Leucine-rich repeat transmembrane neuronal protein 1

2

3

High-throughput

0.574

High

222387

CDS1
Phosphatidate cytidylyltransferase 1

2

3

High-throughput

0.574

High

222342

AT1B1
Sodium/potassium-transporting ATPase subunit beta-1

1

6

High-throughput

0.536

High

222344

S10A8
Protein S100-A8

1

4

High-throughput

0.536

High

222345

S10A9
Protein S100-A9

1

7

High-throughput

0.536

High

222346

INVO
Involucrin

1

4

High-throughput

0.536

High

222347

CATH
Pro-cathepsin H [Cleaved into: Cathepsin H mini chain; Cathepsin H

1

1

High-throughput

0.536

High

222349

PLAK
Junction plakoglobin

1

1

High-throughput

0.536

High

222353

ZA2G
Zinc-alpha-2-glycoprotein

1

2

High-throughput

0.536

High

222354

CALX
Calnexin

1

5

High-throughput

0.536

High

222355

SPB3
Serpin B3

1

3

High-throughput

0.536

High

222358

SCN4A
Sodium channel protein type 4 subunit alpha

1

3

High-throughput

0.536

High

222359

SPB4
Serpin B4

1

3

High-throughput

0.536

High

222361

SPB8
Serpin B8

1

3

High-throughput

0.536

High

222363

RAB14
Ras-related protein Rab-14

1

2

High-throughput

0.536

High

222364

NGAL
Neutrophil gelatinase-associated lipocalin

1

1

High-throughput

0.536

High

222388

S10AG
Protein S100-A16

1

7

High-throughput

0.536

High

222391

KI2L4
Killer cell immunoglobulin-like receptor 2DL4

1

5

High-throughput

0.536

High

222380

STING
Stimulator of interferon genes protein

1

1

Small-scale

0.515

High

222350

PPAP
Prostatic acid phosphatase

1

0

High-throughput

0.513

High

222351

SAP3
Ganglioside GM2 activator

1

0

High-throughput

0.513

High

222352

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

0

High-throughput

0.513

High

222390

GSDMA
Gasdermin-A

1

0

High-throughput

0.513

High

161851

IMPA2
Inositol monophosphatase 2

1

1

High-throughput

0.489

High

222336

CATL2
Cathepsin L2

1

1

High-throughput

0.489

High

222356

S10A7
Protein S100-A7

1

7

High-throughput

0.489

High

222357

CASPE
Caspase-14

1

1

High-throughput

0.489

High

222360

ACADV
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial

1

1

High-throughput

0.489

High

222366

KDSR
3-ketodihydrosphingosine reductase

1

10

High-throughput

0.489

High

222368

EBP
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

1

2

High-throughput

0.489

High

222369

SMTL2
Smoothelin-like protein 2

1

4

High-throughput

0.489

High

222378

S1A7A
Protein S100-A7A

1

7

High-throughput

0.489

High

222382

WDFY1
WD repeat and FYVE domain-containing protein 1

1

2

High-throughput

0.489

High

222384

GHDC
GH3 domain-containing protein

1

4

High-throughput

0.489

High

222385

DR9C7
Short-chain dehydrogenase/reductase family 9C member 7

1

3

High-throughput

0.489

High

222395

CBPA4
Carboxypeptidase A4

1

1

High-throughput

0.489

High

222348

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

222376

MAVS
Mitochondrial antiviral-signaling protein

1

1

Small-scale

0.479

High

222339

RIGI
Antiviral innate immune response receptor RIG-I

1

6

Small-scale

0.470

High

222392

IFIH1
Interferon-induced helicase C domain-containing protein 1

1

5

Small-scale

0.470

High

222372

RIF1
Telomere-associated protein RIF1

1

2

High-throughput

0.457

High

222341

P53
Cellular tumor antigen p53

1

2

High-throughput

0.437

High

222383

TM192
Transmembrane protein 192

1

3

High-throughput

0.437

High

222386

T185A
Transmembrane protein 185A

3

0

High-throughput

0.347

High

222367

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

0

High-throughput

0.282

High

222337

LX12B
Arachidonate 12-lipoxygenase, 12R-type

1

0

High-throughput

0.279

Low

222343

ARGI1
Arginase-1

1

0

High-throughput

0.279

Low

222373

STUM
Protein stum homolog

1

0

High-throughput

0.279

Low

222374

PLBL1
Phospholipase B-like 1

1

0

High-throughput

0.279

Low

222394

QCR9
Cytochrome b-c1 complex subunit 9

1

0

High-throughput

0.279

Low

222396

GUAD
Guanine deaminase

1

0

High-throughput

0.279

Low

222397

NSG2
Neuronal vesicle trafficking-associated protein 2

1

0

High-throughput

0.265

Low

222371

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

0

High-throughput

0.251

Low


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Last updated: 11Aug2025