Protein: E4F1
Transcription factor E4F1 (EC 2.3.2.27) (E4F transcription factor 1) (Putative E3 ubiquitin-protein ligase E4F1) (RING-type E3 ubiquitin transferase E4F1) (Transcription factor E4F) (p120E4F) (p50E4F)

Gene: E4F1
Organism: Homo sapiens
Interactions: 101
UniProt ID: Q66K89

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

196620

ZBT24
Zinc finger and BTB domain-containing protein 24

2

19

High-throughput

0.811

High

317607

ZBT11
Zinc finger and BTB domain-containing protein 11

2

9

High-throughput

0.811

High

934234

CSK21
Casein kinase II subunit alpha

2

4

High-throughput

0.811

High

1146273

ZN770
Zinc finger protein 770

2

4

High-throughput

0.811

High

1146275

ZSC25
Zinc finger and SCAN domain-containing protein 25

2

19

High-throughput

0.811

High

1146276

ZN574
Zinc finger protein 574

2

4

High-throughput

0.811

High

1146278

ZN771
Zinc finger protein 771

2

19

High-throughput

0.811

High

1146284

ZN579
Zinc finger protein 579

2

5

High-throughput

0.811

High

1146296

HIC2
Hypermethylated in cancer 2 protein

2

20

High-throughput

0.811

High

1146300

GZF1
GDNF-inducible zinc finger protein 1

2

12

High-throughput

0.811

High

1146309

ZNF70
Zinc finger protein 70

2

7

High-throughput

0.811

High

386910

P53
Cellular tumor antigen p53

3

7

Small-scale

0.669

High

1050673

FHL2
Four and a half LIM domains protein 2

2

20

Small-scale

0.644

High

1038459

HDAC1
Histone deacetylase 1

2

7

Small-scale

0.634

High

273134

SURF6
Surfeit locus protein 6

2

1

High-throughput

0.628

High

563124

YBOX3
Y-box-binding protein 3

2

7

High-throughput

0.628

High

907965

RS16
Small ribosomal subunit protein uS9

2

2

High-throughput

0.628

High

924031

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

2

1

High-throughput

0.628

High

931215

YBOX1
Y-box-binding protein 1

2

7

High-throughput

0.628

High

951600

RL19
Large ribosomal subunit protein eL19

2

3

High-throughput

0.628

High

971211

H11
Histone H1.1

2

9

High-throughput

0.628

High

1116319

LARP7
La-related protein 7

2

2

High-throughput

0.628

High

1146291

VWCE
von Willebrand factor C and EGF domain-containing protein

2

20

High-throughput

0.628

High

1146299

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

2

2

High-throughput

0.628

High

1146305

DDX21
Nucleolar RNA helicase 2

2

2

High-throughput

0.628

High

1146310

ABT1
Activator of basal transcription 1

2

1

High-throughput

0.628

High

741059

ZEB1
Zinc finger E-box-binding homeobox 1

1

19

Small-scale

0.618

High

898651

RL26
Large ribosomal subunit protein uL24

2

5

High-throughput

0.611

High

846134

RT29
Small ribosomal subunit protein mS29

2

0

High-throughput

0.602

High

907360

RS8
Small ribosomal subunit protein eS8

2

0

High-throughput

0.602

High

990114

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

2

0

High-throughput

0.602

High

1146282

ZC3H8
Zinc finger CCCH domain-containing protein 8

2

0

High-throughput

0.602

High

1146293

PTCD3
Small ribosomal subunit protein mS39

2

0

High-throughput

0.602

High

374381

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

3

High-throughput

0.575

High

947582

RT05
Small ribosomal subunit protein uS5m

2

1

High-throughput

0.574

High

948599

RT09
Small ribosomal subunit protein uS9m

2

2

High-throughput

0.574

High

1016966

FBLN3
EGF-containing fibulin-like extracellular matrix protein 1

2

20

High-throughput

0.574

High

1102487

LIN41
E3 ubiquitin-protein ligase TRIM71

2

20

High-throughput

0.574

High

1146279

LTBP4
Latent-transforming growth factor beta-binding protein 4

2

20

High-throughput

0.574

High

1146288

RT31
Small ribosomal subunit protein mS31

2

1

High-throughput

0.574

High

1146314

RT02
Small ribosomal subunit protein uS2m

2

1

High-throughput

0.574

High

1146315

RT18C
Small ribosomal subunit protein bS18m

2

2

High-throughput

0.574

High

414319

RB
Retinoblastoma-associated protein

1

2

Small-scale

0.573

High

369798

ESR1
Estrogen receptor

2

9

High-throughput

0.571

High

1146306

RASF1
Ras association domain-containing protein 1

1

0

Small-scale

0.569

High

1146311

RL26L
Ribosomal protein uL24-like

2

5

High-throughput

0.558

High

857481

HMGA2
High mobility group protein HMGI-C

1

0

Small-scale

0.554

High

790806

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

4

Small-scale

0.552

High

455545

PARP1
Poly [ADP-ribose] polymerase 1

1

0

Small-scale

0.537

High

846994

SMCA4
Transcription activator BRG1

1

0

Small-scale

0.537

High

1031546

ATM
Serine-protein kinase ATM

1

3

Small-scale

0.536

High

242491

DKC1
H/ACA ribonucleoprotein complex subunit DKC1

1

1

High-throughput

0.536

High

268753

SF3B1
Splicing factor 3B subunit 1

1

1

High-throughput

0.536

High

577989

RL17
Large ribosomal subunit protein uL22

1

3

High-throughput

0.536

High

642774

ELAV4
ELAV-like protein 4

1

1

High-throughput

0.536

High

898354

RS3A
Small ribosomal subunit protein eS1

1

1

High-throughput

0.536

High

980401

NOTC2
Neurogenic locus notch homolog protein 2

1

15

High-throughput

0.536

High

1060546

ZN638
Zinc finger protein 638

1

1

High-throughput

0.536

High

1146281

ZCHC9
Zinc finger CCHC domain-containing protein 9

1

3

High-throughput

0.536

High

1146289

RENT1
Regulator of nonsense transcripts 1

1

1

High-throughput

0.536

High

1146298

FOXB1
Forkhead box protein B1

1

2

High-throughput

0.536

High

763347

AN32A
Acidic leucine-rich nuclear phosphoprotein 32 family member A

1

1

Small-scale

0.515

High

911162

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.513

High

920223

RS24
Small ribosomal subunit protein eS24

1

0

High-throughput

0.513

High

1146317

RT18B
Small ribosomal subunit protein mS40

1

0

High-throughput

0.513

High

171407

SMAD9
Mothers against decapentaplegic homolog 9

1

2

High-throughput

0.508

High

470416

H2A1
Histone H2A type 1

1

2

High-throughput

0.489

High

947244

RT10
Small ribosomal subunit protein uS10m

1

1

High-throughput

0.489

High

1059065

LTBP2
Latent-transforming growth factor beta-binding protein 2

1

20

High-throughput

0.489

High

1146277

H1FNT
Testis-specific H1 histone

1

3

High-throughput

0.489

High

1146303

MOV10
Helicase MOV-10

1

1

High-throughput

0.489

High

1146307

STAU2
Double-stranded RNA-binding protein Staufen homolog 2

1

12

High-throughput

0.489

High

1146308

RBM28
RNA-binding protein 28

1

3

High-throughput

0.489

High

1146297

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

6

High-throughput

0.481

High

760118

RL3
Large ribosomal subunit protein uL3

1

4

High-throughput

0.479

High

917426

H4
Histone H4

1

1

High-throughput

0.479

High

1146274

Q6IT96
Histone deacetylase

1

7

Small-scale

0.479

High

1146280

LNX2
Ligand of Numb protein X 2

1

4

Small-scale

0.479

High

1146286

LNX1
E3 ubiquitin-protein ligase LNX

1

5

Small-scale

0.479

High

1146302

RENT2
Regulator of nonsense transcripts 2

1

0

High-throughput

0.460

High

1085772

IF16
Gamma-interferon-inducible protein 16

1

0

High-throughput

0.458

High

1146287

GATD1
GATA zinc finger domain-containing protein 1

1

0

High-throughput

0.458

High

1146294

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

0

Small-scale

0.458

High

889286

KR107
Keratin-associated protein 10-7

1

20

High-throughput

0.439

High

944283

PRKDC
DNA-dependent protein kinase catalytic subunit

1

3

Small-scale

0.408

High

1038123

ATR
Serine/threonine-protein kinase ATR

1

3

Small-scale

0.408

High

946891

RT22
Small ribosomal subunit protein mS22

2

0

High-throughput

0.328

High

947405

RT35
Small ribosomal subunit protein mS35

2

0

High-throughput

0.328

High

947951

RT11
Small ribosomal subunit protein uS11m

2

0

High-throughput

0.328

High

1146292

RT24
Small ribosomal subunit protein uS3m

2

0

High-throughput

0.328

High

1146301

RPF1
Ribosome production factor 1

2

0

High-throughput

0.328

High

1146312

RT33
Small ribosomal subunit protein mS33

2

0

High-throughput

0.328

High

1146313

RT07
Small ribosomal subunit protein uS7m

2

0

High-throughput

0.328

High

1146316

RT23
Small ribosomal subunit protein mS23

2

0

High-throughput

0.328

High

1146290

RL36L
Ribosomal protein eL42-like

2

0

High-throughput

0.318

High

1146304

XAGE1
X antigen family member 1

2

0

High-throughput

0.313

High

315376

NSA2
Ribosome biogenesis protein NSA2 homolog

1

0

High-throughput

0.279

Low

947071

RT25
Small ribosomal subunit protein mS25

1

0

High-throughput

0.279

Low

1146283

KRI1
Protein KRI1 homolog

1

0

High-throughput

0.279

Low

1146295

DDX27
Probable ATP-dependent RNA helicase DDX27

1

0

High-throughput

0.279

Low

1146285

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024