HitPredict

Interactor 1: DYR1A (Q61214)
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.11.23) (EC 2.7.12.1) (Dual specificity YAK1-related kinase) (MP86) (Protein kinase minibrain homolog) (MNBH)
Gene: Dyrk1a

Interactor 2: DYR1A (Q61214)
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.11.23) (EC 2.7.12.1) (Dual specificity YAK1-related kinase) (MP86) (Protein kinase minibrain homolog) (MNBH)
Gene: Dyrk1a

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.52 1.00 0.726

The method score is based on:

Property Details
Experiments 9070862, 21965663
Identification Methods two hybrid, protein kinase assay
Interaction Type physical association, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains Pkinase~Pkinase
Common GO terms GO:0004674 - protein serine/threonine kinase activity
GO:0004712 - protein serine/threonine/tyrosine kinase activity
GO:0004713 - protein tyrosine kinase activity
GO:0004715 - non-membrane spanning protein tyrosine kinase activity
GO:0005524 - ATP binding
and 25 others

more...
Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 763
Mm

1 763
+ Rn
+ Hs
+ Hs
+ Hs
+ Hs
+ Sp
+ Hs
+ Dm
+ Hs
+ Hs
+ Zm
+ Dm
+ At
+ Sc
+ Hs
+ At

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Last updated: 11Aug2025