HitPredict

Interactor 1: WWC2 (Q6AWC2)
Protein WWC2 (BH-3-only member B) (WW domain-containing protein 2)
Gene: WWC2

Interactor 2: LATS2 (Q9NRM7)
Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase)
Gene: LATS2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	24682284
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0035329 - hippo signaling
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1192 Hs			1 1088
+	Hs
		1311652 KIBRA_HUMAN (1-1192): 0: 925: 48.79		LATS2_HUMAN (1-1088): 0: 990: 100.00
+	Hs
		1448711 WWC3_HUMAN (6-1192): 0: 903: 43.07		LATS2_HUMAN (1-1088): 0: 990: 100.00
+	Hs
		349125 WWC2_HUMAN (1-1192): 0: 1073: 100.00		LATS1_HUMAN (1-1083): 0: 731: 49.57
+	Hs
		349148 KIBRA_HUMAN (1-1192): 0: 925: 48.79		LATS1_HUMAN (1-1083): 0: 731: 49.57
+	Hs
		349289 WWC3_HUMAN (6-1192): 0: 903: 43.07		LATS1_HUMAN (1-1083): 0: 731: 49.57
+	Dm
		1467330 KIBRA_DROME (8-1190): 0: 710: 29.60		WARTS_DROME (166-1013): 9.23e-138: 445: 41.60
+	Hs
		1401118 MAGI1_HUMAN (1-97): 8.81e-33: 140: 38.53		LATS2_HUMAN (1-1088): 0: 990: 100.00
+	Hs
		349245 SMUF2_HUMAN (1-143): 1.62e-40: 163: 21.11		LATS1_HUMAN (1-1083): 0: 731: 49.57
+	Hs
		349237 WWP1_HUMAN (6-143): 3.65e-36: 150: 22.67		LATS1_HUMAN (1-1083): 0: 731: 49.57
+	Hs
		349265 WWOX_HUMAN (5-193): 8.82e-38: 149: 20.71		LATS1_HUMAN (1-1083): 0: 731: 49.57
+	Hs
		349122 MAGI3_HUMAN (9-97): 1.56e-34: 146: 43.82		LATS1_HUMAN (1-1083): 0: 731: 49.57
+	Hs
		349210 MAGI1_HUMAN (1-97): 8.81e-33: 140: 38.53		LATS1_HUMAN (1-1083): 0: 731: 49.57
+	Hs
		349204 ITCH_HUMAN (10-143): 1.83e-32: 138: 24.83		LATS1_HUMAN (1-1083): 0: 731: 49.57
+	Hs
		131647 WWP2_HUMAN (3-143): 7.2e-31: 133: 23.84		LATS1_HUMAN (1-1083): 0: 731: 49.57
+	Hs
		349239 SAV1_HUMAN (4-88): 4.56e-27: 116: 38.82		LATS1_HUMAN (1-1083): 0: 731: 49.57
+	Hs
		728385 ITCH_HUMAN (10-143): 1.83e-32: 138: 24.83		AKT1_HUMAN (532-1043): 7.82e-142: 436: 22.16
+	Hs
		605781 ITCH_HUMAN (10-143): 1.83e-32: 138: 24.83		KAPCA_HUMAN (633-1025): 3.08e-132: 406: 31.23
+	Hs
		1148355 MAGI2_HUMAN (2-113): 1.74e-35: 149: 36.84		KS6A1_HUMAN (519-977): 1.35e-79: 278: 20.34
+	Hs
		1148345 MAGI3_HUMAN (9-97): 1.56e-34: 146: 43.82		KS6A1_HUMAN (519-977): 1.35e-79: 278: 20.34
+	Hs
		1148381 MAGI1_HUMAN (1-97): 8.81e-33: 140: 38.53		KS6A1_HUMAN (519-977): 1.35e-79: 278: 20.34