HitPredict

Interactor 1: MED15 (Q6NS15)
Mediator of RNA polymerase II transcription subunit 15 (Activator-recruited cofactor 105 kDa component) (ARC105) (xARC105) (Mediator complex subunit 15)
Gene: MED15

Interactor 2: Q90YE5 (Q90YE5)
Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member)
Gene: smad3.L

Species: Xenopus laevis

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	12167862
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 777 Xl			1 425
+	Xl
		1235201 MED15_XENLA (408-777): 1.02e-73: 257: 100.00		Q6IRR4_XENLA (1-425): 0: 600: 82.23
+	Hs
		1014586 MED15_HUMAN (4-139): 1.13e-35: 146: 69.12		SMAD3_HUMAN (1-425): 0: 634: 95.31
+	Hs
		1153879 MED15_HUMAN (4-139): 1.13e-35: 146: 69.12		SMAD2_HUMAN (1-425): 0: 602: 82.01
+	Hs
		1153996 MED15_HUMAN (4-139): 1.13e-35: 146: 69.12		SMAD1_HUMAN (1-425): 0: 580: 59.87
+	Hs
		1153850 MY18A_HUMAN (131-654): 5.87e-25: 114: 9.18		SMAD2_HUMAN (1-425): 0: 602: 82.01
+	Dm
		837199 MED15_DROME (6-121): 2.48e-24: 110: 30.66		MAD_DROME (1-425): 0: 595: 60.41
+	Hs
		181890 PLEC_HUMAN (138-452): 1.35e-09: 64.2: 17.51		SMAD9_HUMAN (1-425): 0: 581: 59.05
+	Xl
		1237804 MED15_XENLA (408-777): 1.02e-73: 257: 100.00		Q9W639_XENLA (23-414): 4.95e-130: 387: 32.95
+	Hs
		1106674 MED15_HUMAN (4-139): 1.13e-35: 146: 69.12		SMAD4_HUMAN (23-414): 2.6e-130: 388: 32.37
+	Hs
		270805 ROCK2_HUMAN (155-592): 1.65e-19: 96.3: 10.97		SMAD4_HUMAN (23-414): 2.6e-130: 388: 32.37
+	Hs
		271701 HIP1R_HUMAN (106-564): 5.93e-18: 90.9: 11.68		SMAD4_HUMAN (23-414): 2.6e-130: 388: 32.37
+	Hs
		1106576 MRCKG_HUMAN (165-660): 7.78e-16: 84.4: 11.69		SMAD4_HUMAN (23-414): 2.6e-130: 388: 32.37